Document Detail


Induction of structural chromosome aberrations and sister chromatid exchanges in human lymphocytes in vitro by aristolochic acid.
MedLine Citation:
PMID:  6885046     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The medicinal use of Aristolochia clematitis has been known for some time. The main active agent of this medicinal plant is aristolochic acid, a nitrophenanthrenecarbonic acid. Very recently, however, the Federal Health Office withdrew the licence for all drugs containing aristolochic acid, because of the well-founded suspicion that aristolochic acid may be a very potent carcinogen. We investigated the induction of structural chromosome aberrations and sister chromatid exchanges (SCEs) by aristolochic acid in human lymphocytes in vitro. Cells were treated with the agent tested throughout culture time and during the G0 phase of the cell cycle. We tested concentrations over a range of 1 to 20 micrograms/ml. Both treatment conditions resulted in an increased aberration frequency. The induction of gaps and breaks as well as the induction of SCEs showed a dose-dependent increase. The number of SCEs per metaphase was enhanced by a factor of 2 to 3. If conventional cytogenetic methods had been applied in time, one would have recognized the mutagenic risk of aristolochic acid earlier.
Authors:
G Abel; O Schimmer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human genetics     Volume:  64     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1983  
Date Detail:
Created Date:  1983-10-21     Completed Date:  1983-10-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  131-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aristolochic Acids*
Carcinogens / toxicity*
Chromosome Aberrations*
Crossing Over, Genetic / drug effects*
Dose-Response Relationship, Drug
Humans
Lymphocytes / drug effects*,  ultrastructure
Metaphase / drug effects
Phenanthrenes / toxicity*
Sister Chromatid Exchange / drug effects*
Chemical
Reg. No./Substance:
0/Aristolochic Acids; 0/Carcinogens; 0/Phenanthrenes; 313-67-7/aristolochic acid I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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