Document Detail


Induction of spermatogenesis in thalassaemia.
MedLine Citation:
PMID:  3144468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In an attempt to induce or to augment pubertal development and to achieve spermatogenesis, 10 gonadotropin-deficient thalassemic patients 15 to 23 years of age (mean 18.9 years) were treated with exogenous gonadotropins for 1 to 4 years (mean 2.1 years). Seven patients produced sperm during human chorionic gonadotropin (hCG) treatment given for 6 to 14 months. However, full spermatogenesis was achieved only when human menopausal gonadotropin was added to hCG regimen. In one patient, despite cessation of gonadotropin treatment, sexual potency, libido, and spermatogenetic capacity were maintained during the past 2 1/2 years. Our study indicates that it is possible to induce or to restore spermatogenesis in the majority of thalassemic patients and that gonadotrope cells may not be irreversibly damaged by iron deposition.
Authors:
V De Sanctis; C Vullo; M Katz; B Wonke; C Nannetti; B Bagni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  50     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-30     Completed Date:  1989-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  969-75     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, Unità Sanitaria Locale 31, Arcispedale S. Anna, Ferrara, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Chorionic Gonadotropin / pharmacology
Humans
Male
Menotropins / pharmacology
Spermatogenesis / drug effects*
Testosterone / blood
Thalassemia / physiopathology*
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 58-22-0/Testosterone; 61489-71-2/Menotropins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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