| Induction of spermatogenesis in thalassaemia. | |
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MedLine Citation:
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PMID: 3144468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an attempt to induce or to augment pubertal development and to achieve spermatogenesis, 10 gonadotropin-deficient thalassemic patients 15 to 23 years of age (mean 18.9 years) were treated with exogenous gonadotropins for 1 to 4 years (mean 2.1 years). Seven patients produced sperm during human chorionic gonadotropin (hCG) treatment given for 6 to 14 months. However, full spermatogenesis was achieved only when human menopausal gonadotropin was added to hCG regimen. In one patient, despite cessation of gonadotropin treatment, sexual potency, libido, and spermatogenetic capacity were maintained during the past 2 1/2 years. Our study indicates that it is possible to induce or to restore spermatogenesis in the majority of thalassemic patients and that gonadotrope cells may not be irreversibly damaged by iron deposition. |
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Authors:
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V De Sanctis; C Vullo; M Katz; B Wonke; C Nannetti; B Bagni |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Fertility and sterility Volume: 50 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-01-30 Completed Date: 1989-01-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 969-75 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Unità Sanitaria Locale 31, Arcispedale S. Anna, Ferrara, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Chorionic Gonadotropin / pharmacology Humans Male Menotropins / pharmacology Spermatogenesis / drug effects* Testosterone / blood Thalassemia / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 58-22-0/Testosterone; 61489-71-2/Menotropins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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