Document Detail

Induction of spermatogenesis and achievement of pregnancy after microsurgical varicocelectomy in men with azoospermia and severe oligoasthenospermia.
MedLine Citation:
PMID:  9660424     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To characterize treatment outcome after varicocele repair in men with azoospermia and severe oligoasthenospermia. DESIGN: Prospective nonrandomized study. SETTING: University-based medical center. PATIENT(S): Seventy-eight men with a palpable varicocele and absolute azoospermia (n = 22) or severe oligoasthenospermia (n = 56). INTERVENTION(S): Microsurgical varicocelectomy. MAIN OUTCOME MEASURE(S): Sperm count and pregnancy rate. RESULT(S): Twelve (55%) of the 22 men with azoospermia and 35 (69%) of the 51 men with zero motile sperm before surgery had motile sperm observed in their ejaculate after varicocele repair. The total number of motile sperm per ejaculate increased from 0.08 +/- 0.02 x 10(6) before varicocelectomy to 7.2 +/- 2.3 x 10(6) afterward. Twenty-four men (31%) contributed to pregnancies leading to live births (15 unassisted [19%]), including 3 men with azoospermia preoperatively. CONCLUSION(S): Varicocele repair resulted in the induction or enhancement of spermatogenesis for most men with azoospermia or severe oligoasthenospermia. Unassisted pregnancies after varicocele repair in men with profound abnormalities of spermatogenesis are possible. Varicocele repair should be considered for all men with azoospermia and severe oligoasthenospermia.
G J Matthews; E D Matthews; M Goldstein
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  70     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-07-16     Completed Date:  1998-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  71-5     Citation Subset:  IM    
Center for Male Reproductive Medicine and Microsurgery, Department of Urology, The New York Hospital-Cornell Medical Center, New York 10021, USA.
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MeSH Terms
Follicle Stimulating Hormone / blood
Oligospermia / etiology*
Sperm Count
Sperm Motility / physiology
Spermatogenesis / physiology*
Testis / physiopathology
Varicocele / complications,  physiopathology,  surgery*
Reg. No./Substance:
9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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