| Induction of skin sensitization is augmented in Nrf2-deficient mice. | |
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MedLine Citation:
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PMID: 23143620 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node assay was performed in wild-type and Nrf2-deficient mice using 2,4-dinitrochlorobenzene. The Nrf2-deficient mice show a more pronounced response, indicating that Nrf2 is involved in dampening the induction of skin sensitization. |
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Authors:
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Jochem W van der Veen; Eric R Gremmer; Jolanda P Vermeulen; Henk van Loveren; Janine Ezendam |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-11 |
Journal Detail:
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Title: Archives of toxicology Volume: - ISSN: 1432-0738 ISO Abbreviation: Arch. Toxicol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417615 Medline TA: Arch Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Toxicogenomics, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands, Jochem.van.der.Veen@rivm.nl. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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