Document Detail

Induction of sister chromatid exchanges and chromosome damage by gossypol in bone marrow cells of mice.
MedLine Citation:
PMID:  2874644     Owner:  NLM     Status:  MEDLINE    
The chromosome-damaging potential of gossypol was evaluated by scoring sister chromatid exchanges (SCEs), determining the percentage of pulverized metaphases and the mitotic index in bone marrow cells of mice. Bone marrow cells were collected approximately 21 hours after the intraperitoneal (0,20,40,80, or 160 micrograms/g) and oral (0,40,80, or 160 micrograms/g) administration of gossypol acetic acid. Irrespective of the dosing schedule (single or multiple doses), the vehicle used (physiological saline, corn oil, or 10% aqueous ethanol), and the route of administration, the mean SCE count per cell was significantly higher (P less than 0.05) in gossypol-treated groups than their control counterparts. At 80 and 160 micrograms/g dose levels, the occurrence of metaphase chromosome pulverization was significantly greater, while mitotic index values were markedly lower than those of the corresponding control values. The results suggest that gossypol is a potentially mutagenic and clastogenic agent in murine bone marrow cells.
B N Nayak; H S Buttar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Teratogenesis, carcinogenesis, and mutagenesis     Volume:  6     ISSN:  0270-3211     ISO Abbreviation:  Teratog., Carcinog. Mutagen.     Publication Date:  1986  
Date Detail:
Created Date:  1986-09-22     Completed Date:  1986-09-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8100917     Medline TA:  Teratog Carcinog Mutagen     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  83-91     Citation Subset:  IM    
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MeSH Terms
Bone Marrow / drug effects
Cells, Cultured
Chromosomes / drug effects*
Gossypol / pharmacology*
Mitotic Index / drug effects
Mutagenicity Tests
Sister Chromatid Exchange / drug effects*
Reg. No./Substance:

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