Document Detail

Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27.
MedLine Citation:
PMID:  21893418     Owner:  NLM     Status:  MEDLINE    
Accumulating evidence indicates that IL-27, a member of the IL-12 family of cytokines, alleviates the severity of autoimmune diseases in both mice and men. The IL-27-induced activation of signal transducer and activator of transcription (Stat)1 and Stat3 promotes the generation of IL-10- producing type 1 regulatory T (Tr1) cells that inhibit effector T cells. In addition, IL-27 also suppresses the development of pathogenic IL-17-producing CD4(+) T cells (T(H)17) cells suggesting that pharmacological manipulations of IL-27 signaling pathway could be exploited therapeutically in regulating tissue inflammation. Here, we review how IL-27 controls inflammation through the regulation of Tr1 and T(H)17 responses.
Caroline Pot; Lionel Apetoh; Amit Awasthi; Vijay K Kuchroo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-09-03
Journal Detail:
Title:  Seminars in immunology     Volume:  23     ISSN:  1096-3618     ISO Abbreviation:  Semin. Immunol.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-05     Completed Date:  2012-03-02     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  9009458     Medline TA:  Semin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  438-45     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Autoimmune Diseases / immunology
Interleukin-10 / biosynthesis*,  immunology
Interleukins / immunology*
T-Lymphocytes, Regulatory / immunology*
Th17 Cells / immunology*
Grant Support
AI039671/AI/NIAID NIH HHS; AI056299/AI/NIAID NIH HHS; NS030843/NS/NINDS NIH HHS; P01 AI039671/AI/NIAID NIH HHS; P01 AI039671-14/AI/NIAID NIH HHS; P01 AI039671-15/AI/NIAID NIH HHS; P01 AI039671-16/AI/NIAID NIH HHS; P01 AI056299/AI/NIAID NIH HHS; P01 AI056299-08/AI/NIAID NIH HHS; P01 AI056299-09/AI/NIAID NIH HHS; R01 NS030843/NS/NINDS NIH HHS; R01 NS030843-18A2/NS/NINDS NIH HHS; R37 NS030843/NS/NINDS NIH HHS; R37 NS030843-16/NS/NINDS NIH HHS; R37 NS030843-17/NS/NINDS NIH HHS
Reg. No./Substance:
0/Interleukins; 130068-27-8/Interleukin-10

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