Document Detail


Induction of pyloric hypertrophy by pentagastrin. An animal model for infantile hypertrophic pyloric stenosis.
MedLine Citation:
PMID:  773789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Administration of pentagastrin in depot form to 20 pregnant bitches produced pyloric hypertrophy in about 28% and gastroduodenal ulceration in about 16% of their pups. The two lesions were not necessarily found in the same individuals. Histological appearances of the pylorus in affected pups closely resembled those of human infantile pyloric stenosis.
Authors:
J A Dodge; A A Karim
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Gut     Volume:  17     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1976 Apr 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  280-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Dogs
Female
Hypertrophy
Maternal-Fetal Exchange
Pentagastrin* / administration & dosage
Peptic Ulcer / chemically induced
Pregnancy
Pyloric Stenosis / chemically induced*,  congenital,  pathology
Pylorus / pathology
Chemical
Reg. No./Substance:
5534-95-2/Pentagastrin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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