| Induction of pulsatile secretion of leptin in horses following thyroidectomy. | |
| | |
MedLine Citation:
|
PMID: 17283235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Endocrine characteristics of Quarter Horse-type mares were determined during a 68 h feed deprivation and again in the same mares following surgical thyroidectomy (THX). A crossover experimental design was implemented, in which mares received brome hay available ad libitum (FED) or were food deprived (RES) for 68 h. Blood samples were collected every 20 min for 48 h, beginning 20 h after the onset of food deprivation. Concentrations of triiodothyronine and thyroxine were undetectable post-THX. Plasma concentrations of thyrotropin were greater post-THX versus pre-THX (P<0 x 001). Plasma concentrations of leptin were greater in the THX FED group than in the THX RES group (P<0 x 01). The existence of leptin pulse secretion was found only in post-THX compared with the same horses pre-THX (P=0 x 02). We theorize that non-pulsatile secretion of leptin may have contributed to the survival of this species, as it evolved in the regions of seasonal availability of food. Lack of pulsatile secretion of leptin may contribute to the accumulation of energy stores by modulating leptin sensitivity. |
| | |
Authors:
|
Preston R Buff; Nat T Messer; Andria M Cogswell; David A Wilson; Philip J Johnson; Duane H Keisler; Venkataseshu K Ganjam |
Related Documents
:
|
19379545 - Food intake and prevalence of obesity in brazil: an ecological analysis. 19857495 - Gene structure, recombinant expression and functional characterization of grass carp le... 9756525 - Leptin does not fully account for the satiety activity of adipose tissue-conditioned me... 14601135 - Long-term control of food intake and body weight by hydrodynamics-based delivery of pla... 8583195 - Procrastination by pigeons: preference for larger, more delayed work requirements. 9554065 - Copper toxicosis in sheep: a case report. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: The Journal of endocrinology Volume: 192 ISSN: 0022-0795 ISO Abbreviation: J. Endocrinol. Publication Date: 2007 Feb |
Date Detail:
|
Created Date: 2007-02-06 Completed Date: 2007-04-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: England |
Other Details:
|
Languages: eng Pagination: 353-9 Citation Subset: IM |
Affiliation:
|
Department of Biomedical Sciences, University of Missouri-Columbia, Columbia, Missouri 56211, USA. pbuff@ads.msstate.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Energy Metabolism* Evolution Female Food Deprivation* Horses / physiology* Leptin / blood, secretion* Radioimmunoassay / methods Secretory Rate Species Specificity Thyroidectomy* Thyrotropin / blood |
| Chemical | |
Reg. No./Substance:
|
0/Leptin; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gastric ghrelin cell development is hampered and plasma ghrelin is reduced by delayed weaning in rat...
Next Document: Mutual regulation of vasopressin- and oxytocin-induced glucagon secretion in V1b vasopressin recepto...