Document Detail

Induction of pulsatile secretion of leptin in horses following thyroidectomy.
MedLine Citation:
PMID:  17283235     Owner:  NLM     Status:  MEDLINE    
Endocrine characteristics of Quarter Horse-type mares were determined during a 68 h feed deprivation and again in the same mares following surgical thyroidectomy (THX). A crossover experimental design was implemented, in which mares received brome hay available ad libitum (FED) or were food deprived (RES) for 68 h. Blood samples were collected every 20 min for 48 h, beginning 20 h after the onset of food deprivation. Concentrations of triiodothyronine and thyroxine were undetectable post-THX. Plasma concentrations of thyrotropin were greater post-THX versus pre-THX (P<0 x 001). Plasma concentrations of leptin were greater in the THX FED group than in the THX RES group (P<0 x 01). The existence of leptin pulse secretion was found only in post-THX compared with the same horses pre-THX (P=0 x 02). We theorize that non-pulsatile secretion of leptin may have contributed to the survival of this species, as it evolved in the regions of seasonal availability of food. Lack of pulsatile secretion of leptin may contribute to the accumulation of energy stores by modulating leptin sensitivity.
Preston R Buff; Nat T Messer; Andria M Cogswell; David A Wilson; Philip J Johnson; Duane H Keisler; Venkataseshu K Ganjam
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  192     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-06     Completed Date:  2007-04-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  353-9     Citation Subset:  IM    
Department of Biomedical Sciences, University of Missouri-Columbia, Columbia, Missouri 56211, USA.
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MeSH Terms
Energy Metabolism*
Food Deprivation*
Horses / physiology*
Leptin / blood,  secretion*
Radioimmunoassay / methods
Secretory Rate
Species Specificity
Thyrotropin / blood
Reg. No./Substance:
0/Leptin; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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