Document Detail

Induction of the proto-oncogene fos by nerve growth factor.
MedLine Citation:
PMID:  2997786     Owner:  NLM     Status:  MEDLINE    
Nerve growth factor (NGF) causes the differentiation of PC12 cells to sympathetic neuron-like cells and also induces a rapid but transient expression of fos mRNA and protein. fos mRNA transcripts can be detected 5 min after the addition of NGF, are maximally abundant after 30 min, and then their levels decrease. fos protein synthesis parallels the expression of fos mRNA, and the induced fos proteins are located in the nucleus. cAMP, epidermal growth factor, the phorbol ester phorbol 12-myristate 13-acetate, and K+ depolarization also induce the fos gene. Growth of PC12 cells in the presence of dexamethasone, which induces differentiation into chromaffin-like cells, is not accompanied by fos expression. We propose that while fos gene induction is associated with the differentiation of PC12 cells to sympathetic nerve, its enhanced expression is primarily involved in the anabolic responses induced by NGF and many growth factors.
W Kruijer; D Schubert; I M Verma
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  82     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-12-05     Completed Date:  1985-12-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7330-4     Citation Subset:  IM    
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MeSH Terms
Bucladesine / pharmacology
Cell Differentiation / drug effects*
Cell Line
Dexamethasone / pharmacology
Epidermal Growth Factor / pharmacology
Gene Expression Regulation / drug effects*
Neoplasm Proteins / biosynthesis
Nerve Growth Factors / pharmacology*
Pheochromocytoma / genetics,  pathology
Potassium / pharmacology
Proto-Oncogene Proteins / biosynthesis,  genetics*
Proto-Oncogene Proteins c-fos
RNA, Messenger / analysis
RNA, Neoplasm / analysis
Tetradecanoylphorbol Acetate / pharmacology
Transcriptional Activation
Reg. No./Substance:
0/Neoplasm Proteins; 0/Nerve Growth Factors; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-fos; 0/RNA, Messenger; 0/RNA, Neoplasm; 16561-29-8/Tetradecanoylphorbol Acetate; 362-74-3/Bucladesine; 50-02-2/Dexamethasone; 62229-50-9/Epidermal Growth Factor; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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