| Induction of preneoplastic lesions by sodium arsenite in human fetal respiratory epithelia in organ culture. | |
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MedLine Citation:
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PMID: 7729386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of sodium arsenite (As) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on epithelia of human fetal trachea and bronchiolar epithelia of human fetal lung were studied by using organ-cultured explants. In epithelium of human fetal trachea, 34 microM MNNG induced hyperplasia, metaplasia, and dysplasia; 1 microM As induced hyperplasia; and 3-9 microM As induced hyperplasia and cellular atypia. In glandular epithelium of human fetal trachea, 34 microM MNNG induced hyperplasia and metaplasia; 1 microM As did not induce obvious changes; and 3-9 microM As induced hyperplasia and epidermoid metaplasia with nuclear atypia. In bronchiolar epithelium of human fetal lung, the induction of dysplasia was observed for 1 microM As. Arsenic-induced preneoplastic lesions support the conclusion of epidemiological studies that arsenic is carcinogenic to human lung. |
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Authors:
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J T Dong; C N Zhou; X M Luo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Environmental research Volume: 68 ISSN: 0013-9351 ISO Abbreviation: Environ. Res. Publication Date: 1995 Jan |
Date Detail:
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Created Date: 1995-05-30 Completed Date: 1995-05-30 Revised Date: 2006-10-30 |
Medline Journal Info:
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Nlm Unique ID: 0147621 Medline TA: Environ Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 39-43 Citation Subset: IM |
Affiliation:
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Cancer Institute, Chinese Academy of Medical Sciences, Beijing. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arsenites
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adverse effects* Bronchi / drug effects, embryology, pathology Epithelium / drug effects, pathology Fetus / drug effects*, pathology Humans Hyperplasia / chemically induced, pathology Lung / drug effects, embryology, pathology Lung Neoplasms / chemically induced*, pathology Methylnitronitrosoguanidine / adverse effects Organ Culture Techniques Precancerous Conditions / chemically induced*, pathology Sodium Compounds / adverse effects* Trachea / drug effects, embryology, pathology Tracheal Neoplasms / chemically induced*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Arsenites; 0/Sodium Compounds; 13768-07-5/sodium arsenite; 70-25-7/Methylnitronitrosoguanidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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