Document Detail


Induction of preneoplastic lesions by sodium arsenite in human fetal respiratory epithelia in organ culture.
MedLine Citation:
PMID:  7729386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of sodium arsenite (As) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on epithelia of human fetal trachea and bronchiolar epithelia of human fetal lung were studied by using organ-cultured explants. In epithelium of human fetal trachea, 34 microM MNNG induced hyperplasia, metaplasia, and dysplasia; 1 microM As induced hyperplasia; and 3-9 microM As induced hyperplasia and cellular atypia. In glandular epithelium of human fetal trachea, 34 microM MNNG induced hyperplasia and metaplasia; 1 microM As did not induce obvious changes; and 3-9 microM As induced hyperplasia and epidermoid metaplasia with nuclear atypia. In bronchiolar epithelium of human fetal lung, the induction of dysplasia was observed for 1 microM As. Arsenic-induced preneoplastic lesions support the conclusion of epidemiological studies that arsenic is carcinogenic to human lung.
Authors:
J T Dong; C N Zhou; X M Luo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental research     Volume:  68     ISSN:  0013-9351     ISO Abbreviation:  Environ. Res.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-05-30     Completed Date:  1995-05-30     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-43     Citation Subset:  IM    
Affiliation:
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
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MeSH Terms
Descriptor/Qualifier:
Arsenites / adverse effects*
Bronchi / drug effects,  embryology,  pathology
Epithelium / drug effects,  pathology
Fetus / drug effects*,  pathology
Humans
Hyperplasia / chemically induced,  pathology
Lung / drug effects,  embryology,  pathology
Lung Neoplasms / chemically induced*,  pathology
Methylnitronitrosoguanidine / adverse effects
Organ Culture Techniques
Precancerous Conditions / chemically induced*,  pathology
Sodium Compounds / adverse effects*
Trachea / drug effects,  embryology,  pathology
Tracheal Neoplasms / chemically induced*,  pathology
Chemical
Reg. No./Substance:
0/Arsenites; 0/Sodium Compounds; 13768-07-5/sodium arsenite; 70-25-7/Methylnitronitrosoguanidine

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