| Induction of pregnancy during established EAE halts progression of CNS autoimmune injury via pregnancy-specific serum factors. | |
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MedLine Citation:
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PMID: 20950868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiple sclerosis (MS) is a demyelinating disease of the CNS involving T cell targeting of myelin antigens. During pregnancy, women with MS experience decreased relapses followed by a post partum disease flare. Using murine experimental autoimmune encephalomyelitis, we recapitulate pregnancy findings in both relapsing and progressive models. Pregnant mice produced less TNF-α, IL-17 and exhibited reduced CNS pathology relative to non-pregnant controls. Microparticles, called exosomes, shed into the blood during pregnancy were isolated and found to significantly suppress T cell activation relative to those from non-pregnant controls. These results demonstrate the immunosuppressive potential of pregnancy and serum-derived pregnancy exosomes. |
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Authors:
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Natosha N Gatson; Jessica L Williams; Nicole D Powell; Melanie A McClain; Teresa R Hennon; Paul D Robbins; Caroline C Whitacre |
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Publication Detail:
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Type: Journal Article Date: 2010-10-14 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 230 ISSN: 1872-8421 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-14 Completed Date: 2011-02-16 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 105-13 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, 760 Biomedical Research Tower, 460 W 12th Avenue, Columbus, OH 43210-1239, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blotting, Western Cytokines / biosynthesis, immunology Disease Progression Encephalomyelitis, Autoimmune, Experimental / blood*, immunology*, pathology Enzyme-Linked Immunosorbent Assay Exosomes / immunology*, metabolism Female Lymphocyte Activation / immunology Mice Mice, Inbred C57BL Pregnancy / blood*, immunology* Reverse Transcriptase Polymerase Chain Reaction Spinal Cord / immunology, pathology T-Lymphocytes / immunology |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS048316-01/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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