Document Detail

Induction of photosensitivity in cultured rat pineal affects Aa-nat regulation.
MedLine Citation:
PMID:  12711374     Owner:  NLM     Status:  MEDLINE    
In a previous investigation we have demonstrated that neonatal rat pineal may become photosensitive if removed from the animal at post-natal day 1 and cultured for 7 days. In the present study we demonstrated that Aa-nat mRNA, the key enzyme in melatonin biosynthetic pathway, is affected by illumination in photosensitive pineal, and Aa-nat transcription in photosensitive pineal, but not in adult or non photosensitive pineals, is up-regulated by BMAL1:CLOCK.
Chiaki Fukuhara; Gianluca Tosini
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research. Developmental brain research     Volume:  142     ISSN:  0165-3806     ISO Abbreviation:  Brain Res. Dev. Brain Res.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-04-24     Completed Date:  2003-08-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8908639     Medline TA:  Brain Res Dev Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  219-21     Citation Subset:  IM; S    
Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, 720 Westview Dr. SW, Atlanta, GA 30310-1495, USA.
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MeSH Terms
ARNTL Transcription Factors
Animals, Newborn
Arylamine N-Acetyltransferase / genetics*
Basic Helix-Loop-Helix Transcription Factors
Cells, Cultured
Gene Expression Regulation, Enzymologic / genetics
Melatonin / biosynthesis*
Photic Stimulation*
Pineal Gland / enzymology*,  growth & development*
RNA, Messenger / metabolism
Signal Transduction / genetics*
Transcription Factors / genetics,  metabolism
Transcription, Genetic / genetics
Up-Regulation / genetics*
Grant Support
Reg. No./Substance:
0/ARNTL Transcription Factors; 0/Basic Helix-Loop-Helix Transcription Factors; 0/RNA, Messenger; 0/Transcription Factors; 73-31-4/Melatonin; EC N-Acetyltransferase

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