| Induction of parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene. | |
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MedLine Citation:
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PMID: 20127819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Amyotrophic lateral sclerosis is a progressive and fatal disease caused by selective death of motor neurons, and a number of these patients carry mutations in the superoxide dismutase 1 (SOD1) gene involved in ameliorating oxidative stress. Recent studies indicate that oxidative stress and disruption of mitochondrial homeostasis is a common mechanism for motor neuron degeneration in amyotrophic lateral sclerosis and the loss of midbrain dopamine neurons in Parkinson's disease. Therefore, the present study investigated the presence and alterations of familial Parkinson's disease-related proteins, PINK1 and DJ-1, in spinal motor neurons of G93ASOD1 transgenic mouse model of amyotrophic lateral sclerosis. Following onset of disease, PINK1 and DJ-1 protein expression increased in the spinal motor neurons. The activated form of p53 also increased and translocated to the nuclei of spinal motor neurons, followed by increased expression of p53-activated gene 608 (PAG608). This is the first report demonstrating that increased expression of PAG608 correlates with activation of phosphorylated p53 in spinal motor neurons of an amyotrophic lateral sclerosis model. These results provide further evidence of the profound correlations between spinal motor neurons of amyotrophic lateral sclerosis and parkinsonism-related proteins. |
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Authors:
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Nobutoshi Morimoto; Makiko Nagai; Kazunori Miyazaki; Yasuyuki Ohta; Tomoko Kurata; Yasushi Takehisa; Yoshio Ikeda; Tohru Matsuura; Masato Asanuma; Koji Abe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroscience research Volume: 88 ISSN: 1097-4547 ISO Abbreviation: J. Neurosci. Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2010-07-12 Revised Date: 2012-06-19 |
Medline Journal Info:
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Nlm Unique ID: 7600111 Medline TA: J Neurosci Res Country: United States |
Other Details:
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Languages: eng Pagination: 1804-11 Citation Subset: IM |
Affiliation:
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Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, Okayama, Japan. morinobu@cc.okayama-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals DNA-Binding Proteins / genetics, metabolism Gene Expression Regulation / genetics* Mice Mice, Inbred C57BL Mice, Transgenic Motor Neurons / metabolism* Nuclear Proteins / genetics, metabolism Oncogene Proteins / genetics, metabolism* Protein Kinases / genetics, metabolism* Spinal Cord / cytology* Superoxide Dismutase / genetics* Tumor Suppressor Protein p53 / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/DJ-1 protein, mouse; 0/DNA-Binding Proteins; 0/Nuclear Proteins; 0/Oncogene Proteins; 0/Tumor Suppressor Protein p53; 0/Wig1 protein, mouse; EC 1.15.1.-/SOD1 G93A protein; EC 1.15.1.1/Superoxide Dismutase; EC 2.7.-/Protein Kinases; EC 2.7.11.1/PTEN-induced putative kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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