Document Detail

Induction of ovulation in polycystic ovary syndrome with a combination of a luteinizing hormone-releasing hormone analog and exogenous gonadotropins.
MedLine Citation:
PMID:  2954858     Owner:  NLM     Status:  MEDLINE    
Eight clomiphene citrate (150 mg/day for 5 days)-resistant anovulatory women with polycystic ovary were included in this study. A luteinizing hormone-releasing hormone (LH-RH) analog, D-Trp-6-LH-RH, 100 micrograms subcutaneous-per day, induced a hypogonadotropic state within varying periods but at most within 3 weeks, after an initial flare-up effect characterized by slight increase in ovarian size in four patients and in the other four by cysts that disappeared rapidly. On the 28th day or 15 to 20 days after menstruation for subsequent cycles, during maintenance of D-Trp-6-LH-RH therapy, a usual gonadotropin regimen was carried out in 33 cycles. Human menopausal gonadotropins obtained follicular maturation in all cycles. However, there was never the growth of a single dominant follicle but always of several follicles. Human chorionic gonadotropin then induced ovulation in 31 cycles (94%). Luteal phase was normal in 28 and inadequate in 3 of the 31 ovulatory cycles. Hyperstimulation, generally mild to moderate but rather severe in 2 cycles, was constant. Five pregnancies were obtained. The overall pregnancy rate was 15% per cycle and 17.8% per normoovulatory cycle. This study showed that an associated treatment with an LH-RH analog enables gonadotropins to achieve ovulation regularly with an encouraging number of pregnancies but at a risk of hyperstimulation.
B Charbonnel; M Krempf; P Blanchard; F Dano; C Delage
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  47     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-07-29     Completed Date:  1987-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  920-4     Citation Subset:  IM    
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MeSH Terms
Chorionic Gonadotropin / therapeutic use
Clomiphene / therapeutic use
Drug Resistance
Gonadotropin-Releasing Hormone / analogs & derivatives*,  therapeutic use
Infertility, Female / drug therapy,  etiology
Luteinizing Hormone / blood
Menotropins / therapeutic use
Ovarian Follicle / drug effects,  physiology
Ovulation Induction*
Polycystic Ovary Syndrome / complications*
Reg. No./Substance:
0/Chorionic Gonadotropin; 33515-09-2/Gonadotropin-Releasing Hormone; 57773-63-4/Triptorelin; 61489-71-2/Menotropins; 9002-67-9/Luteinizing Hormone; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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