| Induction of ovulation in infertile women with hyperandrogenism and insulin resistance. | |
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MedLine Citation:
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PMID: 11120504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The polycystic ovary syndrome is a common cause of anovulatory infertility. Women with severe insulin resistance are a unique subset of polycystic ovary syndrome. The syndrome of hyperandrogenism, insulin resistance, and acanthosis nigricans (HAIR-AN syndrome) is one presentation of the insulin-resistant subset of polycystic ovary syndrome. Insulin resistance and hyperandrogenism are caused by genetic and environmental factors. In women with anovulatory infertility caused by hyperandrogenism and insulin resistance, clomiphene citrate treatment often fails to result in pregnancy. For these women, weight loss and insulin sensitizers can be effective methods of inducing ovulation and pregnancy and may reduce the number of clomiphene-resistant women with polycystic ovary syndrome who are treated with gonadotropins, ovarian surgery, or in vitro fertilization-embryo transfer. |
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Authors:
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R L Barbieri |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 183 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-01-08 Completed Date: 2001-01-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1412-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acanthosis Nigricans
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complications Female Humans Hyperandrogenism / complications* Hypoglycemic Agents / therapeutic use Infertility, Female / complications*, etiology, physiopathology, therapy* Insulin Resistance* Metformin / therapeutic use Ovulation Induction* Polycystic Ovary Syndrome / complications Syndrome |
| Grant Support | |
ID/Acronym/Agency:
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HD-29164/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 657-24-9/Metformin |
| Comments/Corrections | |
Comment In:
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Am J Obstet Gynecol. 2001 Sep;185(3):777-8
[PMID:
11568818
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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