Document Detail

Induction of osteoarthrosis in the rabbit knee joint.
MedLine Citation:
PMID:  6154558     Owner:  NLM     Status:  MEDLINE    
Medial meniscectomy and the creation of "bucket-handle" lesions of the medial meniscus induce mild to moderate osteoarthrotic changes in the knee joints of mature rabbits. The osteoarthrotic lesions studied by gross inspection and histological sections, almost exclusively involve the medial tibial articular cartilage. The pathologic changes begin superficially, pass to the deeper layers, and are characterized by a loss of the glistening of the cartilage surface, peripheral osteophytes, structural irregularities of the matrix, peripheral cloning, hypocellularity, and diminished amounts of glycosaminoglycan. Osteoarthrosis was assessed from 2 to 16 months following surgery using a grading system from 0 (normal) to 15 (severe degeneration). The mean grades at the various time periods studied range from 3.5 to 7. The mild to moderate nature of the osteoarthrosis is shown by the development of the abnormalities without rapid progression to the severely destroyed joints which characterize many other models.
F Shapiro; M J Glimcher
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  -     ISSN:  0009-921X     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:    1980 Mar-Apr
Date Detail:
Created Date:  1980-07-22     Completed Date:  1980-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  287-95     Citation Subset:  AIM; IM    
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MeSH Terms
Cartilage, Articular / cytology,  pathology*,  surgery
Disease Models, Animal
Osteoarthritis / etiology,  pathology*
Staining and Labeling
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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