| Induction of osteoarthritis and metabolic inflammation by a very high fat diet in mice: Effects of short-term exercise. | |
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MedLine Citation:
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PMID: 21953366 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To test the hypotheses that obesity due to a very high fat diet induces knee osteoarthritis, and that short-term wheel running exercise protects against obesity-induced knee osteoarthritis by reducing systemic inflammation and metabolic dysregulation. METHODS: Male C57BL/6J mice were fed either a control (13.5% kcal fat) or very high fat diet (60% kcal fat) from 12-24 wks of age. From 20-24 wks, half of the animals were housed with running wheels. Knee osteoarthritis severity was determined via histopathology, and serum cytokines were measured using a multiplex bead immunoassay and ELISAs. Body composition was quantified by dual-energy X-ray absorptiometry, and insulin resistance was assessed by glucose tolerance testing. RESULTS: A very high fat diet increased osteoarthritis scores and serum leptin, adiponectin, KC (mouse analog of IL-8), MIG (monokine induced by interferon-gamma, or CXCL9), and interleukin 1 receptor antagonist (IL-1Ra) levels in proportion to percent body fat, which increased 3-fold compared to controls. Wheel running reduced osteoarthritis progression in the medial femur of obese mice. Exercise disrupted the clustering of cytokine expression and improved glucose tolerance without reducing body fat or cytokine levels. CONCLUSION: Obesity induced by a very high-fat diet causes osteoarthritis and systemic inflammation in proportion to body fat. Increased joint loading is not sufficient to explain the increased incidence of knee osteoarthritis with obesity as wheel running is protective rather than damaging. Exercise improves glucose tolerance and disrupts the co-expression of pro-inflammatory cytokines, suggesting that increased aerobic exercise may act independent of weight loss in promoting joint health. © 2011 American College of Rheumatology. |
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Authors:
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Timothy M Griffin; Janet L Huebner; Virginia B Kraus; Zhen Yan; Farshid Guilak |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-27 |
Journal Detail:
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Title: Arthritis and rheumatism Volume: - ISSN: 1529-0131 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 by the American College of Rheumatology. |
Affiliation:
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Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, United States of America; Program in Free Radical Biology and Aging, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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