| Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. | |
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MedLine Citation:
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PMID: 7526776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The amount of messenger RNA encoding human inducible nitric oxide synthase and the presence and distribution of NADPH diaphorase were determined in tissue sections from multiple sclerosis (MS) and control brains. Levels of human nitric oxide synthase messenger RNA were markedly elevated in MS brains when compared to normal control brains. NADPH diaphorase activity, a histochemical stain reflecting nitric oxide synthase catalytic activity, was detected in reactive astrocytes in active demyelinating MS lesions and at the edge of chronic active demyelinating lesions. Control brains did not contain NADPH diaphorase-positive astrocytes. These results implicate the free radical nitric oxide in the pathogenesis of demyelinating MS lesions. |
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Authors:
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L Bö; T M Dawson; S Wesselingh; S Mörk; S Choi; P A Kong; D Hanley; B D Trapp |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of neurology Volume: 36 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1994-12-13 Completed Date: 1994-12-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 778-86 Citation Subset: IM |
Affiliation:
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Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amino Acid Oxidoreductases / biosynthesis* Base Sequence Brain / enzymology* Enzyme Induction Humans Immunoenzyme Techniques Middle Aged Molecular Sequence Data Multiple Sclerosis / enzymology* NADPH Dehydrogenase / metabolism Nitric Oxide Synthase |
| Grant Support | |
ID/Acronym/Agency:
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NS01578/NS/NINDS NIH HHS; NS29818/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 1.14.13.39/Nitric Oxide Synthase; EC 1.4.-/Amino Acid Oxidoreductases; EC 1.6.99.1/NADPH Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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