Document Detail

Induction of neutral endopeptidase and angiotensin-converting enzyme activity of SK-N-SH cells in vitro by quercetin and resveratrol.
MedLine Citation:
PMID:  12227197     Owner:  NLM     Status:  MEDLINE    
Quercetin and resveratrol are weak inhibitors of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE) activity of the neuroblastoma cell line SK-N-SH. The long term incubation of the cells for 4 days with quercetin, resveratrol and a combination of both substances in concentrations lower than necessary for inhibition of NEP and ACE activity induced the cellular enzyme activity of NEP and ACE associated with an inhibition of cellular proliferation. The long term treatment of neuroblastoma cells with quercetin and resveratrol enhanced the differentiation state of the cells. Taking into account the significance of NEP and ACE for the degradation of amyloid beta peptides, the effect of quercetin and resveratrol as constituents of red wine for a neuroprotective activity is discussed.
M F Melzig; F Escher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Die Pharmazie     Volume:  57     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-09-13     Completed Date:  2002-10-08     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  556-8     Citation Subset:  IM    
Institut für Pharmazie, Humboldt-Universität zu Berlin, Germany.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Brain Neoplasms / enzymology
Cell Count
Cell Division / drug effects
Cell Line
Enzyme Induction / drug effects
Enzyme Inhibitors / pharmacology*
Neprilysin / biosynthesis*
Neuroblastoma / enzymology
Peptidyl-Dipeptidase A / biosynthesis*
Protease Inhibitors / pharmacology
Quercetin / pharmacology*
Stilbenes / pharmacology*
Tumor Cells, Cultured
Wine / analysis
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Enzyme Inhibitors; 0/Protease Inhibitors; 0/Stilbenes; 117-39-5/Quercetin; EC A; EC; Q369O8926L/resveratrol

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