Document Detail


Induction of neoangiogenesis in ischemic myocardium by human growth factors: first clinical results of a new treatment of coronary heart disease.
MedLine Citation:
PMID:  9495299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The present article is a report of our animal experiments and also of the first clinical results of a new treatment for coronary heart disease using the human growth factor FGF-I (basic fibroblast growth factor) to induce neoangiogenesis in the ischemic myocardium. METHODS AND RESULTS: FGF-I was obtained from strains of Escherichia coli by genetic engineering, then isolated and highly purified. Several series of animal experiments demonstrated the apathogenic action and neoangiogenic potency of this factor. After successful conclusion of the animal experiments, it was used clinically for the first time. FGF-I (0.01 mg/kg body weight) was injected close to the vessels after the completion of internal mammary artery (IMA)/left anterior descending coronary artery (LAD) anastomosis in 20 patients with three-vessel coronary disease. All the patients had additional peripheral stenoses of the LAD or one of its diagonal branches. Twelve weeks later, the IMA bypasses were selectively imaged by intra-arterial digital subtraction angiography and quantitatively evaluated. In all the animal experiments, the development of new vessels in the ischemic myocardium could be demonstrated angiographically. The formation of capillaries could also be demonstrated in humans and was found in all cases around the site of injection. A capillary network sprouting from the proximal part of the coronary artery could be shown to have bypassed the stenoses and rejoined the distal parts of the vessel. CONCLUSIONS: We believe that the use of FGF-I for myocardial revascularization is in principle a new concept and that it may be particularly suitable for patients with additional peripheral stenoses that cannot be revascularized surgically.
Authors:
B Schumacher; P Pecher; B U von Specht; T Stegmann
Related Documents :
11053699 - Transthoracic doppler echocardiographic comparison of left internal mammary grafts to l...
3280159 - Clinical implications of internal mammary artery bypass grafts: the coronary artery sur...
9814789 - Mammary coronary artery anastomosis without cardiopulmonary bypass through minithoracot...
10952349 - Left internal thoracic artery harvesting in pleural symphyses under minimally invasive ...
7620699 - Endothelin eta and etb mrna and receptors expressed by smooth muscle in the human vascu...
20930679 - Aortic valve replacement by ministernotomy in redo patients with previous left internal...
20645099 - Current outcomes of simultaneous carotid endarterectomy and coronary artery bypass graf...
10617039 - Absence of vasospasm in radial artery cabg on high-dose norepinephrine.
23509049 - Serial carotid mri identifies rupture of a vulnerable plaque resulting in amaurosis fugax.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Circulation     Volume:  97     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-17     Completed Date:  1998-03-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  645-50     Citation Subset:  AIM; IM    
Affiliation:
Klinik für Thorax-, Herz und Gefässchirurgie, Klinikum Fulda, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Capillaries / drug effects
Chick Embryo
Collateral Circulation / drug effects*
Combined Modality Therapy
Coronary Angiography
Coronary Circulation / drug effects*
Coronary Disease / drug therapy*,  physiopathology,  radiography,  surgery
Female
Fibroblast Growth Factor 2 / pharmacology,  therapeutic use*
Humans
Internal Mammary-Coronary Artery Anastomosis
Male
Middle Aged
Myocardial Revascularization / methods*
Neovascularization, Physiologic / drug effects*
Rabbits
Rats
Rats, Inbred Lew
Recombinant Fusion Proteins / pharmacology,  therapeutic use
Single-Blind Method
Stimulation, Chemical
Chemical
Reg. No./Substance:
0/Recombinant Fusion Proteins; 103107-01-3/Fibroblast Growth Factor 2
Comments/Corrections
Comment In:
Circulation. 1998 Feb 24;97(7):628-9   [PMID:  9495294 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Phenotypic characterization of a novel long-QT syndrome mutation (R1623Q) in the cardiac sodium chan...
Next Document:  Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of...