Document Detail


Induction of multiple reinstatements of ethanol- and sucrose-seeking behavior in Long-Evans rats by the α-2 adrenoreceptor antagonist yohimbine.
MedLine Citation:
PMID:  21863233     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: Developing models to efficiently explore the mechanisms by which stress can mediate reinstatement of drug-seeking behavior is crucial to the development of new pharmacotherapies for alcohol use disorders.
OBJECTIVES: We examined the effects of multiple reinstatement sessions using the pharmacological stressor, yohimbine, in ethanol- and sucrose-seeking rats in order to develop a more efficient model of stress-induced reinstatement.
METHODS: Long-Evans rats were trained to self-administer 10% ethanol with a sucrose-fading procedure, 20% ethanol without a sucrose-fading procedure, or 5% sucrose in 30-min operant self-administration sessions, followed by extinction training. After reaching extinction criteria, the animals were tested once per week with yohimbine vehicle and yohimbine (2 mg/kg), respectively, 30 min prior to the reinstatement sessions or blood collection. Levels of reinstatement and plasma corticosterone (CORT) were determined each week for four consecutive weeks.
RESULTS: Yohimbine induced reinstatement of ethanol- and sucrose-seeking in each of the 4 weeks. Interestingly, the magnitude of the reinstatement decreased for the 10% ethanol group after the first reinstatement session but remained stable for the 20% ethanol group trained without sucrose. Plasma CORT levels in response to injection of both vehicle and yohimbine were significantly higher in the ethanol-trained animals compared to sucrose controls.
CONCLUSIONS: The stable reinstatement in the 20% ethanol group supports the use of this training procedure in studies using within-subject designs with multiple yohimbine reinstatement test sessions. Additionally, these results indicate that the hormonal response to stressors can be altered following extinction from self-administration of relatively modest amounts of ethanol.
Authors:
Jeffrey A Simms; Jemma K Richards; Douglas Mill; Isabel Kanholm; Joan Y Holgate; Selena E Bartlett
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-08-24
Journal Detail:
Title:  Psychopharmacology     Volume:  218     ISSN:  1432-2072     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-12     Completed Date:  2012-02-08     Revised Date:  2014-01-30    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  101-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-2 Receptor Antagonists / pharmacology
Animals
Conditioning, Operant / drug effects*
Corticosterone / blood
Disease Models, Animal
Ethanol / administration & dosage*
Male
Rats
Rats, Long-Evans
Recurrence
Reinforcement Schedule
Self Administration
Stress, Psychological
Sucrose / administration & dosage*
Yohimbine / pharmacology*
Grant Support
ID/Acronym/Agency:
1R01AA017924-01/AA/NIAAA NIH HHS; R01 AA017924/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic alpha-2 Receptor Antagonists; 2Y49VWD90Q/Yohimbine; 3K9958V90M/Ethanol; 57-50-1/Sucrose; W980KJ009P/Corticosterone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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