Document Detail


Induction of morphological and enzymic differentiation in rat pheochromocytoma PC12h cells by stable erbstatin analogues.
MedLine Citation:
PMID:  8223134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Erbstatin, a tyrosine kinase inhibitor, is known to induce transient differentiation in rat pheochromocytoma PC12h cells. The authors tested seven newly synthesized stable erbstatin analogues for their ability to induce neurite formation and acetylcholine esterase in PC12h cells. Among the inhibitors tested hexyl 2,3-dihydroxycinnamate most efficiently induced neurite formation in PC12h cells. Although this analogue is much more stable than erbstatin, the induction by it was again transient. In addition, the analogue weakly induced acetylcholine esterase activity in PC12h cells. Thus hexyl 2,3-dihydroxycinnamate is a potent inducer of morphological differentiation in PC12h cells.
Authors:
Y Watanabe; H Kakeya; E Ikoma; K Umezawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drugs under experimental and clinical research     Volume:  19     ISSN:  0378-6501     ISO Abbreviation:  Drugs Exp Clin Res     Publication Date:  1993  
Date Detail:
Created Date:  1993-12-01     Completed Date:  1993-12-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7802135     Medline TA:  Drugs Exp Clin Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Affiliation:
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholinesterase / biosynthesis
Animals
Cell Differentiation / drug effects
Enzyme Induction / drug effects
Hydroquinones / pharmacology*
Neurites / drug effects,  ultrastructure
PC12 Cells
Rats
Receptor Protein-Tyrosine Kinases / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Hydroquinones; 100827-28-9/erbstatin; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases; EC 3.1.1.7/Acetylcholinesterase

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