| Induction of morphological and enzymic differentiation in rat pheochromocytoma PC12h cells by stable erbstatin analogues. | |
| | |
MedLine Citation:
|
PMID: 8223134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Erbstatin, a tyrosine kinase inhibitor, is known to induce transient differentiation in rat pheochromocytoma PC12h cells. The authors tested seven newly synthesized stable erbstatin analogues for their ability to induce neurite formation and acetylcholine esterase in PC12h cells. Among the inhibitors tested hexyl 2,3-dihydroxycinnamate most efficiently induced neurite formation in PC12h cells. Although this analogue is much more stable than erbstatin, the induction by it was again transient. In addition, the analogue weakly induced acetylcholine esterase activity in PC12h cells. Thus hexyl 2,3-dihydroxycinnamate is a potent inducer of morphological differentiation in PC12h cells. |
| | |
Authors:
|
Y Watanabe; H Kakeya; E Ikoma; K Umezawa |
Related Documents
:
|
16181734 - Neuroprotective effects of the cyanidin-3-o-beta-d-glucopyranoside isolated from mulber... 15051504 - Caspase activation independent of cell death is required for proper cell dispersal and ... 10793234 - Protective effect of nicotine through nicotinic acetylcholine receptor alpha 7 on hypox... 8558244 - Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of pc12 ce... 12417334 - Identification of the nuclear localization signal of p21(cip1) and consequences of its ... 8253534 - Effect of epidermal growth factor and transforming growth factor beta 1 on growth and i... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Drugs under experimental and clinical research Volume: 19 ISSN: 0378-6501 ISO Abbreviation: Drugs Exp Clin Res Publication Date: 1993 |
Date Detail:
|
Created Date: 1993-12-01 Completed Date: 1993-12-01 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 7802135 Medline TA: Drugs Exp Clin Res Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 1-6 Citation Subset: IM |
Affiliation:
|
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholinesterase
/
biosynthesis Animals Cell Differentiation / drug effects Enzyme Induction / drug effects Hydroquinones / pharmacology* Neurites / drug effects, ultrastructure PC12 Cells Rats Receptor Protein-Tyrosine Kinases / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
|
0/Hydroquinones; 100827-28-9/erbstatin; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases; EC 3.1.1.7/Acetylcholinesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The expression of C-myc, N-ras mRNA and its relations to the differentiation of preneoplastic altere...
Next Document: The role of serotonin brain receptors in the analgesic effect of phenazone.