| Induction of mitogen-activated protein kinase phosphatase-1 during acute hypertension. | |
| | |
MedLine Citation:
|
PMID: 9231829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Recently, we demonstrated that elevated blood pressure activates mitogen-activated protein (MAP) kinases in rat aorta. Here we provide evidence that the vascular response to acute hypertension also includes induction of MAP kinase phosphatase-1 (MKP-1), which has been shown to function in the dephosphorylation and inactivation of MAP kinases. Restraint or immobilization stress, which leads to a rapid rise in blood pressure, resulted in a rapid and transient induction of MKP-1 mRNA followed by elevated MKP-1 protein expression in rat aorta. That the induction of MKP-1 by restraint was due to the rise in blood pressure was supported by the finding that several different hypertensive agents (phenylephrine, vasopressin, and angiotensin II) were likewise capable of eliciting the response, and sodium nitroprusside, a nonspecific vasodilator agent that prevented the acute rise in blood pressure in response to the hypertensive agents, abrogated MKP-1 mRNA induction. The in vivo effects could not be mimicked by treatment of cultured aortic smooth muscle cells with similar doses of the hypertensive agents. These findings support a role for MKP-1 in the in vivo regulation of MAP kinase activity during hemodynamic stress. |
| | |
Authors:
|
Q Xu; T W Fawcett; M Gorospe; K Z Guyton; Y Liu; N J Holbrook |
Related Documents
:
|
15071169 - Role of brain and peripheral angiotensin ii in hypertension and altered arterial barore... 3414799 - Enhanced tubuloglomerular feedback during peritubular infusions of angiotensins i and ii. 9551879 - Tissue angiotensin ii concentration in the heart and kidneys in transgenic tsukuba hype... 22426989 - Prevalence of arterial hypertension among seventh-day adventists of the são paulo stat... 15898529 - Worsening of heart failure in becker muscular dystrophy after nonsteroidal anti-inflamm... 6329559 - Diminished sympathetic responsiveness in nephrectomized rats-role of the renin angioten... 2667309 - Urapidil-induced hemodynamic changes in humans. 10905439 - Intradiscal pressure after intradiscal injection of hypertonic saline: an experimental ... 9007799 - Prospective evaluation of pulmonary artery pressures during pulmonary angiography perfo... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Hypertension Volume: 30 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1997 Jul |
Date Detail:
|
Created Date: 1997-08-08 Completed Date: 1997-08-08 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 106-11 Citation Subset: IM; S |
Affiliation:
|
Gene Expression and Aging Section, National Institute on Aging, National Institutes of Health, Baltimore, Md 21224, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Angiotensin II / pharmacology Animals Antihypertensive Agents / pharmacology Blood Pressure / drug effects Blotting, Western Cardiovascular System / enzymology, physiopathology Cells, Cultured Data Interpretation, Statistical Enzyme Activation Gene Expression Regulation, Enzymologic* Hypertension / enzymology*, etiology, physiopathology Male Mitogens / pharmacology Muscle, Smooth, Vascular / cytology, enzymology, metabolism Nitroprusside / pharmacology Phenylephrine / pharmacology Phosphoprotein Phosphatases / genetics*, metabolism* Protein Kinases / genetics*, metabolism* Protein Phosphatase 1 RNA / analysis Rats Rats, Wistar Restraint, Physical Stress, Physiological / complications Vasoconstrictor Agents / pharmacology Vasodilator Agents / pharmacology Vasopressins / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 0/Mitogens; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 11000-17-2/Vasopressins; 11128-99-7/Angiotensin II; 15078-28-1/Nitroprusside; 59-42-7/Phenylephrine; 63231-63-0/RNA; EC 2.7.-/Protein Kinases; EC 3.1.3.16/Phosphoprotein Phosphatases; EC 3.1.3.16/Protein Phosphatase 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Erythrocyte sodium-lithium countertransport in non-modulating offspring and essential hypertensive i...
Next Document: Mechanosensitive cation channels in aortic endothelium of normotensive and hypertensive rats.