|Induction of mitogen-activated protein kinase phosphatase-1 during acute hypertension.|
|PMID: 9231829 Owner: NLM Status: MEDLINE|
|Recently, we demonstrated that elevated blood pressure activates mitogen-activated protein (MAP) kinases in rat aorta. Here we provide evidence that the vascular response to acute hypertension also includes induction of MAP kinase phosphatase-1 (MKP-1), which has been shown to function in the dephosphorylation and inactivation of MAP kinases. Restraint or immobilization stress, which leads to a rapid rise in blood pressure, resulted in a rapid and transient induction of MKP-1 mRNA followed by elevated MKP-1 protein expression in rat aorta. That the induction of MKP-1 by restraint was due to the rise in blood pressure was supported by the finding that several different hypertensive agents (phenylephrine, vasopressin, and angiotensin II) were likewise capable of eliciting the response, and sodium nitroprusside, a nonspecific vasodilator agent that prevented the acute rise in blood pressure in response to the hypertensive agents, abrogated MKP-1 mRNA induction. The in vivo effects could not be mimicked by treatment of cultured aortic smooth muscle cells with similar doses of the hypertensive agents. These findings support a role for MKP-1 in the in vivo regulation of MAP kinase activity during hemodynamic stress.|
|Q Xu; T W Fawcett; M Gorospe; K Z Guyton; Y Liu; N J Holbrook|
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|Type: Comparative Study; Journal Article|
|Title: Hypertension Volume: 30 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1997 Jul|
|Created Date: 1997-08-08 Completed Date: 1997-08-08 Revised Date: 2009-11-19|
Medline Journal Info:
|Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES|
|Languages: eng Pagination: 106-11 Citation Subset: IM; S|
|Gene Expression and Aging Section, National Institute on Aging, National Institutes of Health, Baltimore, Md 21224, USA.|
|APA/MLA Format Download EndNote Download BibTex|
Angiotensin II / pharmacology
Antihypertensive Agents / pharmacology
Blood Pressure / drug effects
Cardiovascular System / enzymology, physiopathology
Data Interpretation, Statistical
Gene Expression Regulation, Enzymologic*
Hypertension / enzymology*, etiology, physiopathology
Mitogens / pharmacology
Muscle, Smooth, Vascular / cytology, enzymology, metabolism
Nitroprusside / pharmacology
Phenylephrine / pharmacology
Phosphoprotein Phosphatases / genetics*, metabolism*
Protein Kinases / genetics*, metabolism*
Protein Phosphatase 1
RNA / analysis
Stress, Physiological / complications
Vasoconstrictor Agents / pharmacology
Vasodilator Agents / pharmacology
Vasopressins / pharmacology
|0/Antihypertensive Agents; 0/Mitogens; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 11000-17-2/Vasopressins; 11128-99-7/Angiotensin II; 15078-28-1/Nitroprusside; 59-42-7/Phenylephrine; 63231-63-0/RNA; EC 2.7.-/Protein Kinases; EC 126.96.36.199/Phosphoprotein Phosphatases; EC 188.8.131.52/Protein Phosphatase 1|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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