Document Detail


Induction of microvillous fusion and pinching-off by concanavalin A.
MedLine Citation:
PMID:  3778478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Concanavalin A (Con A) caused dramatic changes in the structure and function of rat colonic epithelium. The morphological effect was a pronounced, permanent alteration of the microvilli, including fusion and blebbing. The functional change involved an increased permeability to passively transported hydrophilic marker compounds. The functional change was transient in nature. Since coadministration of glucose or mannose inhibited the effect of Con A, the mechanistic effect of Con A probably involves binding to saccharide components of the membrane surface.
Authors:
T Nishihata; P R Burton; L J Caldwell
Related Documents :
766018 - Intracolonic tensions of oxygen and carbon dioxide in germfree, conventional, and gnoto...
3747328 - Accelerated renal cyst development in deconditioned germ-free rats.
12588698 - Effects of bowman-birk inhibitor on rat colon carcinogenesis.
3643718 - Bile acids and the intestinal kallikrein-kinin system.
295088 - Action of depressor-i, a hypotensive phospholipid from bovine brain, on systemic and ar...
1122888 - Suppressed plasma renin activity in adrenal regeneration hypertension.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  140     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-12-15     Completed Date:  1986-12-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  766-72     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Colon / drug effects
Concanavalin A / pharmacology*
Intestinal Absorption / drug effects
Intestinal Mucosa / drug effects*,  ultrastructure
Male
Microscopy, Electron
Microvilli / drug effects
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
11028-71-0/Concanavalin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Postsynaptic densities contain a subtype of protein kinase C.
Next Document:  Evidence for direct binding of Clostridium botulinum type E derivative toxin and its fragments to ga...