Document Detail

Induction of microvillous fusion and pinching-off by concanavalin A.
MedLine Citation:
PMID:  3778478     Owner:  NLM     Status:  MEDLINE    
Concanavalin A (Con A) caused dramatic changes in the structure and function of rat colonic epithelium. The morphological effect was a pronounced, permanent alteration of the microvilli, including fusion and blebbing. The functional change involved an increased permeability to passively transported hydrophilic marker compounds. The functional change was transient in nature. Since coadministration of glucose or mannose inhibited the effect of Con A, the mechanistic effect of Con A probably involves binding to saccharide components of the membrane surface.
T Nishihata; P R Burton; L J Caldwell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  140     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-12-15     Completed Date:  1986-12-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  766-72     Citation Subset:  IM    
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MeSH Terms
Colon / drug effects
Concanavalin A / pharmacology*
Intestinal Absorption / drug effects
Intestinal Mucosa / drug effects*,  ultrastructure
Microscopy, Electron
Microvilli / drug effects
Rats, Inbred Strains
Reg. No./Substance:
11028-71-0/Concanavalin A

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