Document Detail


Induction of microsomal stearoyl-CoA desaturation by the administration of various peroxisome proliferators.
MedLine Citation:
PMID:  6134555     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Male rats were fed a diet containing 0.5% p-chlorophenoxyisobutyric acid (clofibric acid), 1% acetylsalicylic acid, 2% di-(2-ethylhexyl)phthalate, 2% dibutylphthalate, 2% di-(2-ethylhexyl)adipate or 0.5% 4,4'-(isopropylidenedithio)bis(2,6-di-tert-butylphenol)) (probucol) for 7 days. Activity of microsomal stearoyl-CoA desaturation in rat liver was increased, ranging from 2.1 to 3.6 times, in association with an increase in the activity of peroxisomal beta-oxidation and catalase following the administration of clofibric acid, di-(2-ethylhexyl)phthalate, dibutylphthalate or di-(2-ethylhexyl)adipate. The increase in the activity of stearoyl-CoA desaturation by peroxisome proliferators appears to be due to an increase in activity only of the terminal desaturase, but not to changes in either NADH-cytochrome b5 reductase activity or cytochrome b5 content. Unlike peroxisome proliferators, probucol increased little the activity of either microsomal desaturation or peroxisomal beta-oxidation. The percentage of octadecenoic acid in total fatty acid of hepatic microsomes, homogenates and serum was increased markedly by the administration of peroxisome proliferators.
Authors:
Y Kawashima; N Hanioka; M Matsumura; H Kozuka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  752     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-08-26     Completed Date:  1983-08-26     Revised Date:  2013-11-13    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  259-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipates / pharmacology
Animals
Aspirin / pharmacology
Clofibric Acid / pharmacology
Dibutyl Phthalate / pharmacology
Diethylhexyl Phthalate / pharmacology
Enzyme Induction / drug effects
Fatty Acid Desaturases / metabolism*
Lipids / blood
Male
Microbodies / drug effects*
Microsomes, Liver / enzymology*
Organoids / drug effects*
Probucol / pharmacology
Rats
Rats, Inbred Strains
Stearoyl-CoA Desaturase / metabolism*
Chemical
Reg. No./Substance:
0/Adipates; 0/Lipids; 117-81-7/Diethylhexyl Phthalate; 23288-49-5/Probucol; 2BD76YG9SI/dioctyl adipate; 50-78-2/Aspirin; 84-74-2/Dibutyl Phthalate; 882-09-7/Clofibric Acid; EC 1.14.19.-/Fatty Acid Desaturases; EC 1.14.19.1/Stearoyl-CoA Desaturase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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