| Induction of microsomal stearoyl-CoA desaturation by the administration of various peroxisome proliferators. | |
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MedLine Citation:
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PMID: 6134555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Male rats were fed a diet containing 0.5% p-chlorophenoxyisobutyric acid (clofibric acid), 1% acetylsalicylic acid, 2% di-(2-ethylhexyl)phthalate, 2% dibutylphthalate, 2% di-(2-ethylhexyl)adipate or 0.5% 4,4'-(isopropylidenedithio)bis(2,6-di-tert-butylphenol)) (probucol) for 7 days. Activity of microsomal stearoyl-CoA desaturation in rat liver was increased, ranging from 2.1 to 3.6 times, in association with an increase in the activity of peroxisomal beta-oxidation and catalase following the administration of clofibric acid, di-(2-ethylhexyl)phthalate, dibutylphthalate or di-(2-ethylhexyl)adipate. The increase in the activity of stearoyl-CoA desaturation by peroxisome proliferators appears to be due to an increase in activity only of the terminal desaturase, but not to changes in either NADH-cytochrome b5 reductase activity or cytochrome b5 content. Unlike peroxisome proliferators, probucol increased little the activity of either microsomal desaturation or peroxisomal beta-oxidation. The percentage of octadecenoic acid in total fatty acid of hepatic microsomes, homogenates and serum was increased markedly by the administration of peroxisome proliferators. |
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Authors:
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Y Kawashima; N Hanioka; M Matsumura; H Kozuka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 752 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1983 Jul |
Date Detail:
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Created Date: 1983-08-26 Completed Date: 1983-08-26 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 259-64 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipic Acids
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pharmacology Animals Aspirin / pharmacology Clofibric Acid / pharmacology Dibutyl Phthalate / pharmacology Diethylhexyl Phthalate / pharmacology Enzyme Induction / drug effects Fatty Acid Desaturases / metabolism* Lipids / blood Male Microbodies / drug effects* Microsomes, Liver / enzymology* Organoids / drug effects* Probucol / pharmacology Rats Rats, Inbred Strains Stearoyl-CoA Desaturase / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Adipic Acids; 0/Lipids; 103-23-1/dioctyl adipate; 117-81-7/Diethylhexyl Phthalate; 23288-49-5/Probucol; 50-78-2/Aspirin; 84-74-2/Dibutyl Phthalate; 882-09-7/Clofibric Acid; EC 1.14.19.-/Fatty Acid Desaturases; EC 1.14.19.1/Stearoyl-CoA Desaturase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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