| Induction of metastasizing carcinoma in rats and their biological characteristics. | |
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MedLine Citation:
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PMID: 170787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Induction of a spontaneously metastasizing carcinoma in rats was attempted. Four-week-old Sprague-Dawley female rats were thymectomized or/and splenectomized and fed 200 mg (20 mg times 10) of 3-methylcholanthrene from 7 weeks of age. In addition to these treatments, the early-appearing tumors were excised in order to select by isoimmunity the late-appearing ones that were less antigenic. The latter were easily transplanted into normal syngeneic female rats with metastasis to remote organs. This metastasizing capacity of the tumor became an inherent character in syngeneic normal rats from generation to generation of transplantation. With one of these tumors (MRMT-1) many cancer cells were histologically detected in circulating blood 3 days after tumor transplantation and arrested in capillary beds of lungs. The spontaneous metastasis to lymph nodes and lungs was macroscopically found within several weeks after tumor transplantation. |
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Authors:
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Y Harada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta pathologica japonica Volume: 25 ISSN: 0001-6632 ISO Abbreviation: Acta Pathol. Jpn. Publication Date: 1975 Jul |
Date Detail:
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Created Date: 1975-12-23 Completed Date: 1975-12-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372637 Medline TA: Acta Pathol Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 451-61 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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chemically induced,
immunology Animals Carcinoma / chemically induced*, immunology Carcinoma, Intraductal, Noninfiltrating / chemically induced, immunology Female Methylcholanthrene* Neoplasm Metastasis* Neoplasm Transplantation Neoplasms, Experimental / chemically induced, immunology Neoplastic Cells, Circulating Rats Spleen / immunology Thymus Gland / immunology |
| Chemical | |
Reg. No./Substance:
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56-49-5/Methylcholanthrene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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