Document Detail


Induction and maintenance of gastric ulceration in horses in simulated race training.
MedLine Citation:
PMID:  10696292     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gastric ulceration is a prevalent condition of racehorses. A number of models of gastric ulceration have been described, but none mimic the conditions of a horse in training. The objectives of this study were to determine whether gastric ulcers could be induced and maintained in a group of horses in simulated race training. In addition, serum cortisol was measured on a weekly basis to investigate the possibility that stress may be important in the pathogenesis of gastric ulceration. Thirty horses used in the trial were fed Bermuda grass hay and 6 kg of a concentrate diet, and exercised 6 days/week at speed over a distance of 1.6-2.4 km. Serum was collected and gastroendoscopic examinations performed on a weekly basis for the duration of the trial. All horses developed moderate to severe ulceration, and ulcers were maintained for the 56 day period of the trial. Only one horse had signs of abdominal discomfort, which resolved with minimal symptomatic treatment and without the use of anti-ulcer medications. Serum cortisol remained within reference ranges for the duration of the trial. Although there was some variation between the weekly examinations, serum cortisol concentrations were decreased from values obtained at the start of the trial. In this study ulcers developed without the administration of nonsteroidal anti-inflammatory agents or withholding of feed. This model provides a method to study the condition, and to investigate the effects of medications on the healing of ulcers in racehorses.
Authors:
N J Vatistas; R L Sifferman; J Holste; J L Cox; G Pinalto; K T Schultz
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Equine veterinary journal. Supplement     Volume:  -     ISSN:  -     ISO Abbreviation:  Equine Vet J Suppl     Publication Date:  1999 Apr 
Date Detail:
Created Date:  2000-03-24     Completed Date:  2000-03-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9614088     Medline TA:  Equine Vet J Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  40-4     Citation Subset:  IM    
Affiliation:
Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, USA.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Breeding
Diet / veterinary
Female
Horse Diseases / blood,  etiology*,  physiopathology*
Horses
Hydrocortisone / blood
Male
Physical Conditioning, Animal*
Stomach Ulcer / blood,  etiology,  physiopathology,  veterinary*
Stress, Physiological / complications,  veterinary
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone
Comments/Corrections
Comment In:
Equine Vet J Suppl. 1999 Apr;(29):5-6   [PMID:  10696285 ]
Erratum In:
Equine Vet J 1999 Jul;31(4):352

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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