Document Detail

Induction of lymphoma in CDF1 mice by the food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
MedLine Citation:
PMID:  2516847     Owner:  NLM     Status:  MEDLINE    
The mutagenic compound, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), originally isolated from cooked beef, was tested for carcinogenicity in CDF1 mice of both sexes. When PhIP was given in the diet at a concentration of 0.04%, high incidences and early appearances of lymphomas were observed in both sexes during the 579-day experiment.
H Esumi; H Ohgaki; E Kohzen; S Takayama; T Sugimura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of cancer research : Gann     Volume:  80     ISSN:  0910-5050     ISO Abbreviation:  Jpn. J. Cancer Res.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-04-24     Completed Date:  1990-04-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8509412     Medline TA:  Jpn J Cancer Res     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1176-8     Citation Subset:  IM    
Biochemistry Division, National Cancer Center Research Institute, Tokyo.
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MeSH Terms
Lymphoma / chemically induced*
Mice, Inbred Strains
Reg. No./Substance:
0/Imidazoles; 0/Mutagens; 105650-23-5/2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

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