Document Detail


Induction of long-term but reversible unresponsiveness after activation of murine T cell hybridomas.
MedLine Citation:
PMID:  1832295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
T cell receptor (TCR)-mediated stimulation of murine T cell hybridomas induces cell activation and lymphokine production. We have observed that following productive activation, T cell hybridomas become refractory to a subsequent stimulation. Hyporesponsiveness is long-lasting but reversible, and is not due to reduced receptor expression. It is noteworthy that hyporesponsiveness is cell autonomous, persists in spite of cell division and does not require continuous exposure to ligands. Hyporesponsive cells retain the ability to produce lymphokines in response to pharmacological agents bypassing receptor triggering, indicating that they possess a functional enzymatic machinery for interleukin 2 synthesis and secretion. Reduced phosphatidylinositol hydrolysis was observed in these cells in response to TCR stimulation, suggesting that hyporesponsiveness result from defective transduction of activation signals. The development of unresponsiveness following receptor stimulation resembles desensitization, and may thus play an important role in the regulation of an immune response and in the induction of immune tolerance.
Authors:
F Andris; M Van Mechelen; N Legrand; P M Dubois; M Kaufman; J Urbain; O Leo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International immunology     Volume:  3     ISSN:  0953-8178     ISO Abbreviation:  Int. Immunol.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-10-11     Completed Date:  1991-10-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8916182     Medline TA:  Int Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  609-16     Citation Subset:  IM    
Affiliation:
Laboratoire de Physiologie Animale, Université Libre de Bruxelles, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD3
Antigens, Differentiation, T-Lymphocyte
Calcimycin / pharmacology
Cell Membrane / immunology
Hybridomas / drug effects,  immunology*
Immune Tolerance
Interleukin-2 / biosynthesis
Lymphocyte Activation* / drug effects
Mice
Receptors, Antigen, T-Cell
Signal Transduction / immunology
T-Lymphocytes / drug effects,  immunology*
Tetradecanoylphorbol Acetate / pharmacology
Chemical
Reg. No./Substance:
0/Antigens, CD3; 0/Antigens, Differentiation, T-Lymphocyte; 0/Interleukin-2; 0/Receptors, Antigen, T-Cell; 16561-29-8/Tetradecanoylphorbol Acetate; 52665-69-7/Calcimycin

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