| Induction of localized differences in rat uterine radial artery behavior and structure during gestation. | |
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MedLine Citation:
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PMID: 14634590 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The objectives of this study were to investigate differences in diameter and vasoconstriction of premyometrial versus uteroplacental radial arteries and to evaluate the contribution of nitric oxide (NO) to myogenic tone as a function of vessel location. STUDY DESIGN: Radial arteries supplying either the myometrium or placenta were dissected from the uterus of pregnant rats. Constrictor responses to pressure elevation were studied before and after inhibition of endothelial NO synthase (eNOS). RESULTS: Passive lumen diameters of premyometrial and proximal uteroplacental arteries were comparable and significantly smaller than those of distal uteroplacental vessels. High potassium- and pressure-induced responses were also similar in premyometrial and proximal but were virtually absent in distal uteroplacental segments. L-NNA enhanced pressure-induced tone, but was without effect in distal uteroplacental segments. CONCLUSION: Gestational remodeling alters arterial structure and reactivity in a highly localized manner. During pregnancy, enhanced basal production of NO may be an important local mechanism for uterine blood flow regulation. |
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Authors:
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Natalia I Gokina; Maurizio Mandalà; George Osol |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 189 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-11-24 Completed Date: 2003-12-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1489-93 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Given C-220, College of Medicine, University of Vermont, Burlington, VT 05405, USA. Natalia.Gokina@uvm.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / anatomy & histology, drug effects, enzymology, physiology Dose-Response Relationship, Drug Enzyme Inhibitors / pharmacology Female Nitric Oxide Synthase / antagonists & inhibitors, physiology Nitric Oxide Synthase Type III Nitroarginine / pharmacology Placenta / blood supply Potassium / administration & dosage Pregnancy Pregnancy, Animal / physiology* Pressure Rats Rats, Sprague-Dawley Uterus / blood supply* Vasoconstriction* Vasomotor System / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL 067250/HL/NHLBI NIH HHS; R01 HL 63078/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 2149-70-4/Nitroarginine; 7440-09-7/Potassium; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type III; EC 1.14.13.39/Nos3 protein, rat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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