| Induction of a local pseudo-pregnancy via levonorgestrel-loaded microspheres for the treatment of endometriosis in a rabbit model. | |
| | |
MedLine Citation:
|
PMID: 19897855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Endometriosis is a chronic disease that responds to systemic pseudo-pregnancy therapy. However, side effects limit their long-term use, and recurrence often occurs after cessation of medication. Reducing side effects whereas improving therapeutic efficacy of pseudo-pregnancy therapy seems contradictory, but appealing. In order to address this dilemma, the efficacy and side effects of local pseudo-pregnancy therapy were investigated for the first time in an endometriosis animal model. METHODS AND RESULTS: Levonorgestrel-loaded polylactic acid microspheres (LNG-microspheres) were prepared by using an oil-in-water emulsification-solvent evaporation method. Rabbits with experimental endometriosis were randomized to treatment with local pseudo-pregnancy therapy, local blank microspheres, systemic pseudo-pregnancy therapy, ovariectomy or the control. Local pseudo-pregnancy was induced by injection of LNG-microspheres directly into endometrial cysts. Compared with the systemic pseudo-pregnancy group, significantly higher intra-cystic drug levels were maintained for at least 6 months with much lower serum levels in the local pseudo-pregnancy group (P < 0.01). The high intra-cystic levonorgestrel simulated a state of potent pregnancy, which induced size reductions and endometrial atrophy comparable to those of ovariectomy. Moreover, major metabolic parameters and ovarian function were not disturbed by local pseudo-pregnancy therapy. CONCLUSIONS: Induction of a local pseudo-pregnancy could achieve therapeutic efficacy comparable to that of ovariectomy without provoking any marked side effects in a rabbit endometriosis model. Thus it may be a preferable option for patients with endometriosis. |
| | |
Authors:
|
Peng Yuan; Yanhong Huang; Hong Wu; Zenghui Teng; Jianfang Zhang; Xiaoyan Xin |
Related Documents
:
|
3976725 - Reproductive counselling for multiple sclerosis patients. 20947075 - The risk of cytogenetic abnormalities in the late first trimester of pregnancies concei... 3585125 - Unsuccessful in vitro fertilization: a follow-up study. 8554435 - Higher pregnancy rates following treatment of cervical factor with intrauterine insemin... 20586545 - A multicenter, case?control study on risk factors for antepartum stillbirth. 20103495 - Pbde concentrations in women's serum and fecundability. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-07 |
Journal Detail:
|
Title: Human reproduction (Oxford, England) Volume: 25 ISSN: 1460-2350 ISO Abbreviation: Hum. Reprod. Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-01-14 Completed Date: 2010-03-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
|
Languages: eng Pagination: 462-9 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Xijing Hospital, Fourth Military Medical University, No. 17 Changle West Road, Xi'an, Shaan'xi 710032, China. ypfmmu@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Disease Models, Animal Drug Delivery Systems Endometriosis / drug therapy*, pathology Female Levonorgestrel / administration & dosage* Microspheres Pregnancy Pseudopregnancy / chemically induced* Rabbits |
| Chemical | |
Reg. No./Substance:
|
797-63-7/Levonorgestrel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inhibition of proteases involved in embryo implantation by cholesterol sulfate.
Next Document: Patenting human pluripotent cells: balancing commercial, academic and ethical interests.