Document Detail

Induction of large DNA palindrome formation in yeast: implications for gene amplification and genome stability in eukaryotes.
MedLine Citation:
PMID:  8978615     Owner:  NLM     Status:  MEDLINE    
Many amplified genes, including some oncogenes, are organized as large inverted repeats. How such giant palindromes are generated remains largely unknown. Recent studies of a palindrome in the ciliate Tetrahymena suggest a novel mechanism that requires chromosome breakage next to short inverted repeats. The prevalence of short inverted repeats in eukaryotic genomes raises the interesting possibility that this process may occur widely as a response to chromosome damage. Here we demonstrate that in Saccharomyces cerevisiae, large DNA palindromes are formed efficiently, probably by intramolecular recombination, when a double-strand break is introduced next to short inverted repeats. These results suggest a general mechanism for large palindromic DNA formation and reveal an important new source of genome instability resulting from chromosome breakage at selective sites.
D K Butler; L E Yasuda; M C Yao
Related Documents :
2887485 - A mouse homeo box gene, hox-1.5, and the morphological locus, hd, map to within 1 cm on...
15302405 - Evolution of the tandem repeats in thymidylate synthase enhancer region (tser) in prima...
8896555 - Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar atax...
17030915 - An improved multiple-locus variable number of tandem repeats analysis for leptospira in...
21071395 - Arabidopsis thaliana telomeres exhibit euchromatic features.
15618745 - Cyp3a4*18: it is not rare allele in japanese population.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell     Volume:  87     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-01-28     Completed Date:  1997-01-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1115-22     Citation Subset:  IM    
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Base Sequence
Cell Differentiation / genetics
DNA, Fungal / genetics
DNA-Binding Proteins / genetics
Eukaryotic Cells / physiology
Fungal Proteins / genetics
Gene Amplification*
Molecular Sequence Data
Rad52 DNA Repair and Recombination Protein
Regulatory Sequences, Nucleic Acid*
Repetitive Sequences, Nucleic Acid / physiology*
Saccharomyces cerevisiae / cytology,  genetics*
Saccharomyces cerevisiae Proteins
Grant Support
Reg. No./Substance:
0/DNA, Fungal; 0/DNA-Binding Proteins; 0/Fungal Proteins; 0/RAD52 protein, S cerevisiae; 0/Rad52 DNA Repair and Recombination Protein; 0/Saccharomyces cerevisiae Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein...
Next Document:  Transcription activation at class II CAP-dependent promoters: two interactions between CAP and RNA p...