| Induction of labor with vaginal misoprostol plus oxytocin versus oxytocin alone. | |
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MedLine Citation:
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PMID: 20347088 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the effect of an oxytocin infusion alone or preceded by an intravaginal application of misoprostol for labor induction in women with term pregnancies and a low Bishop score. METHODS: This study randomized 100 multiparous women with singleton pregnancies over 38 weeks and a Bishop score less than 6 to receive either a single 50-microg dose of misoprostol intravaginally 3 hours before initiation of the oxytocin infusion or only an oxytocin infusion. The time from induction to delivery, the route of delivery, and maternal and fetal outcomes were analyzed. RESULTS: The mean time from induction to delivery was 9.36+/-1.97 hours in the misoprostol plus oxytocin group and 11.08+/-3.23 in the oxytocin alone group (P=0.002). The rates of vaginal delivery, 1- and 5-minute Agpar scores, placental abruption, and postpartum hemorrhage were similar between the 2 groups, as were the rates of admission to the neonatal intensive care unit. There were no cases of perinatal asphyxia. CONCLUSION: A 50-microg intravaginal application of misoprostol before starting the oxytocin infusion is a more effective method of labor induction than an oxytocin infusion alone for our study population. |
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Authors:
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Osman Balci; Alaa S Mahmoud; Suna Ozdemir; Ali Acar |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2010-03-26 |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 110 ISSN: 1879-3479 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-04 Completed Date: 2010-11-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: Ireland |
Other Details:
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Languages: eng Pagination: 64-7 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, Meram School of Medicine, Selcuk University, Konya, Turkey. drobalci@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abruptio Placentae
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epidemiology Administration, Intravaginal Adult Apgar Score Drug Therapy, Combination Female Humans Infant, Newborn Infusions, Intravenous Labor, Induced / methods* Misoprostol / administration & dosage, therapeutic use* Oxytocics / administration & dosage, therapeutic use* Oxytocin / administration & dosage, therapeutic use* Postpartum Hemorrhage / epidemiology Pregnancy Pregnancy Outcome Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Oxytocics; 50-56-6/Oxytocin; 59122-46-2/Misoprostol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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