Document Detail

Induction of labor with vaginal misoprostol plus oxytocin versus oxytocin alone.
MedLine Citation:
PMID:  20347088     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the effect of an oxytocin infusion alone or preceded by an intravaginal application of misoprostol for labor induction in women with term pregnancies and a low Bishop score. METHODS: This study randomized 100 multiparous women with singleton pregnancies over 38 weeks and a Bishop score less than 6 to receive either a single 50-microg dose of misoprostol intravaginally 3 hours before initiation of the oxytocin infusion or only an oxytocin infusion. The time from induction to delivery, the route of delivery, and maternal and fetal outcomes were analyzed. RESULTS: The mean time from induction to delivery was 9.36+/-1.97 hours in the misoprostol plus oxytocin group and 11.08+/-3.23 in the oxytocin alone group (P=0.002). The rates of vaginal delivery, 1- and 5-minute Agpar scores, placental abruption, and postpartum hemorrhage were similar between the 2 groups, as were the rates of admission to the neonatal intensive care unit. There were no cases of perinatal asphyxia. CONCLUSION: A 50-microg intravaginal application of misoprostol before starting the oxytocin infusion is a more effective method of labor induction than an oxytocin infusion alone for our study population.
Osman Balci; Alaa S Mahmoud; Suna Ozdemir; Ali Acar
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2010-03-26
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  110     ISSN:  1879-3479     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-04     Completed Date:  2010-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  64-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Department of Obstetrics and Gynecology, Meram School of Medicine, Selcuk University, Konya, Turkey.
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MeSH Terms
Abruptio Placentae / epidemiology
Administration, Intravaginal
Apgar Score
Drug Therapy, Combination
Infant, Newborn
Infusions, Intravenous
Labor, Induced / methods*
Misoprostol / administration & dosage,  therapeutic use*
Oxytocics / administration & dosage,  therapeutic use*
Oxytocin / administration & dosage,  therapeutic use*
Postpartum Hemorrhage / epidemiology
Pregnancy Outcome
Time Factors
Reg. No./Substance:
0/Oxytocics; 50-56-6/Oxytocin; 59122-46-2/Misoprostol

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