| Induction of labor at term using isosorbide mononitrate simultaneously with dinoprostone compared to dinoprostone treatment alone: a randomized, controlled trial. | |
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MedLine Citation:
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PMID: 16723101 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We aimed to determine whether isosorbide mononitrate (IMN) given simultaneously with dinoprostone in term pregnancies is superior to dinoprostone alone to promote delivery. STUDY DESIGN: One hundred and twenty nulliparous women at term were randomly assigned to receive per vaginam IMN 40 mg or placebo in addition to 3 mg dinoprostone 2 times daily for up to 2 days. Analysis was by intention to treat. RESULTS: Baseline characteristics of both groups were comparable. The induction to delivery intervals did not differ between the IMN and the placebo group (26.4 +/- 14.4 vs 23.4 +/- 14.8 hours, P = .408). IMN resulted in more headache compared to placebo (32/55 [58.2%] vs 2/55 [3.6%], P < .001). CONCLUSION: Vaginally administered IMN does not play a role in promoting delivery in term pregnancy if given at the same time as dinoprostone. This might reflect its relaxant effect on the uterine fundus, which may overcome its cervical softening effect. |
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Authors:
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Monika M Wölfler; Fabio Facchinetti; Paolo Venturini; Ambros Huber; Hanns Helmer; Peter Husslein; Walter Tschugguel |
Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial Date: 2006-05-24 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 195 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-29 Completed Date: 2006-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1617-22 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intravaginal Adult Delivery, Obstetric Dinoprostone / administration & dosage, adverse effects, therapeutic use* Double-Blind Method Drug Therapy, Combination Female Headache / chemically induced Humans Isosorbide Dinitrate / administration & dosage, adverse effects, analogs & derivatives*, therapeutic use Labor, Induced* Oxytocics / administration & dosage, adverse effects, therapeutic use* Pregnancy Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Oxytocics; 16051-77-7/isosorbide-5-mononitrate; 363-24-6/Dinoprostone; 87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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