Document Detail

Induction of labor at term using isosorbide mononitrate simultaneously with dinoprostone compared to dinoprostone treatment alone: a randomized, controlled trial.
MedLine Citation:
PMID:  16723101     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We aimed to determine whether isosorbide mononitrate (IMN) given simultaneously with dinoprostone in term pregnancies is superior to dinoprostone alone to promote delivery. STUDY DESIGN: One hundred and twenty nulliparous women at term were randomly assigned to receive per vaginam IMN 40 mg or placebo in addition to 3 mg dinoprostone 2 times daily for up to 2 days. Analysis was by intention to treat. RESULTS: Baseline characteristics of both groups were comparable. The induction to delivery intervals did not differ between the IMN and the placebo group (26.4 +/- 14.4 vs 23.4 +/- 14.8 hours, P = .408). IMN resulted in more headache compared to placebo (32/55 [58.2%] vs 2/55 [3.6%], P < .001). CONCLUSION: Vaginally administered IMN does not play a role in promoting delivery in term pregnancy if given at the same time as dinoprostone. This might reflect its relaxant effect on the uterine fundus, which may overcome its cervical softening effect.
Monika M Wölfler; Fabio Facchinetti; Paolo Venturini; Ambros Huber; Hanns Helmer; Peter Husslein; Walter Tschugguel
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial     Date:  2006-05-24
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  195     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-29     Completed Date:  2006-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1617-22     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
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MeSH Terms
Administration, Intravaginal
Delivery, Obstetric
Dinoprostone / administration & dosage,  adverse effects,  therapeutic use*
Double-Blind Method
Drug Therapy, Combination
Headache / chemically induced
Isosorbide Dinitrate / administration & dosage,  adverse effects,  analogs & derivatives*,  therapeutic use
Labor, Induced*
Oxytocics / administration & dosage,  adverse effects,  therapeutic use*
Time Factors
Reg. No./Substance:
0/Oxytocics; 16051-77-7/isosorbide-5-mononitrate; 363-24-6/Dinoprostone; 87-33-2/Isosorbide Dinitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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