| Induction of kinin B1 receptor-dependent vasoconstriction following balloon catheter injury to the rabbit carotid artery. | |
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MedLine Citation:
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PMID: 8032586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Balloon catheter injury to the rabbit carotid artery damaged the endothelium and induced neointima formation over 7 days. The area of intima, expressed as a percentage of the media, was 16.2 +/- 4.2% and 8.2 +/- 0.1% in balloon catheter-injured and sham-operated arteries. 2. Seven days after arterial injury, carotid arteries were isolated and set up as ring preparations in organ baths for isometric tension measurements. Balloon catheter-injured arteries first contracted with noradrenaline (0.01-0.1 microM), contracted further in a concentration-dependent manner to bradykinin (BK; pD2, 5.98 +/- 0.22; Emax, 41.3 +/- 5.2% of KCl) and to des-Arg9-BK (pD2, 7.12 +/- 0.36; Emax, 46.0 +/- 9.9% of KCl). In contrast, vessel segments with endothelium either intact or acutely removed were unresponsive to both BK receptor agonists. 3. The concentration-contraction curves for BK and for des-Arg9-BK were shifted to the right by the B1 receptor antagonist, [Leu8]des-Arg9-BK (3 microM), but not by the selective B2 receptor antagonist, Hoe 140 (1 microM). 4. Thus, BK and its metabolite, des-Arg9-BK act as vasoconstrictor agents following balloon catheter injury. These effects appear to be mediated by activation of B1 receptors. |
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Authors:
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D Pruneau; J M Luccarini; C Robert; P Bélichard |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: British journal of pharmacology Volume: 111 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-08-17 Completed Date: 1994-08-17 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1029-34 Citation Subset: IM |
Affiliation:
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Centre de Recherche, Laboratoires Fournier S.C.A., Daix, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Balloon Animals Bradykinin / pharmacology Carotid Arteries / pathology* Dose-Response Relationship, Drug Male Muscle, Smooth, Vascular / pathology* Rabbits Receptors, Bradykinin / physiology* Vasoconstriction* / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Bradykinin; 58-82-2/Bradykinin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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