Document Detail

Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation.
MedLine Citation:
PMID:  16684588     Owner:  NLM     Status:  MEDLINE    
We have previously used genome-wide transcript profiling to investigate the relationships between changes in gene expression and physiological alterations during the response of the immature mouse uterus to estrogens. Here we describe the identification of a functionally inter-related group of estrogen-responsive genes associated with iron homeostasis, including the iron-binding protein lactotransferrin, the ferroxidase ceruloplasmin, the iron delivery protein lipocalin 2 and the iron-exporter ferroportin. Quantitative real-time PCR revealed that the expression of these genes increases with time during the uterotrophic response, reaching maximal levels in the post-proliferative phase (between 48 and 72 h). In contrast, the heme biosynthesis genes aminolevulinic acid synthase 1 and 2 were maximally induced by estrogen at 2 and 4 h, respectively, prior to increased cell proliferation. Together, these data reveal that estrogen induces the temporally coordinated expression of iron homeostasis genes in the mouse uterus, and suggest an important role for iron metabolism during sex steroid hormone-induced uterine cell growth and differentiation.
Ruth Stuckey; Tom Aldridge; Fei Ling Lim; David J Moore; Helen Tinwell; Nicola Doherty; Reginald Davies; Andrew G Smith; Ian Kimber; John Ashby; George Orphanides; Jonathan G Moggs
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Publication Detail:
Type:  Journal Article     Date:  2006-05-08
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  253     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  22-9     Citation Subset:  IM    
Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, UK.
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MeSH Terms
Cell Differentiation / drug effects
Epithelium / drug effects,  metabolism
Estradiol / pharmacology
Estrogens / pharmacology*
Gene Expression Profiling*
Homeostasis / genetics*
Iron / metabolism*
Models, Biological
Uterus / drug effects*,  growth & development*
Reg. No./Substance:
0/Estrogens; 50-28-2/Estradiol; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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