Document Detail


Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation.
MedLine Citation:
PMID:  16684588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have previously used genome-wide transcript profiling to investigate the relationships between changes in gene expression and physiological alterations during the response of the immature mouse uterus to estrogens. Here we describe the identification of a functionally inter-related group of estrogen-responsive genes associated with iron homeostasis, including the iron-binding protein lactotransferrin, the ferroxidase ceruloplasmin, the iron delivery protein lipocalin 2 and the iron-exporter ferroportin. Quantitative real-time PCR revealed that the expression of these genes increases with time during the uterotrophic response, reaching maximal levels in the post-proliferative phase (between 48 and 72 h). In contrast, the heme biosynthesis genes aminolevulinic acid synthase 1 and 2 were maximally induced by estrogen at 2 and 4 h, respectively, prior to increased cell proliferation. Together, these data reveal that estrogen induces the temporally coordinated expression of iron homeostasis genes in the mouse uterus, and suggest an important role for iron metabolism during sex steroid hormone-induced uterine cell growth and differentiation.
Authors:
Ruth Stuckey; Tom Aldridge; Fei Ling Lim; David J Moore; Helen Tinwell; Nicola Doherty; Reginald Davies; Andrew G Smith; Ian Kimber; John Ashby; George Orphanides; Jonathan G Moggs
Related Documents :
19329638 - Indole acts as an extracellular cue regulating gene expression in vibrio cholerae.
7559648 - Biochemical characterization of a haemophilus influenzae periplasmic iron transport ope...
16352848 - Comparative and functional genomic analysis of prokaryotic nickel and cobalt uptake tra...
24063688 - Genetic analysis of the fbxo42 gene in chinese han patients with parkinson's disease.
10618488 - Transcriptional regulation of fatty acid synthase gene and atp citrate-lyase gene by sp...
16911948 - The methylation status of the tms1/asc gene in cholangiocarcinoma and its clinical sign...
Publication Detail:
Type:  Journal Article     Date:  2006-05-08
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  253     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  22-9     Citation Subset:  IM    
Affiliation:
Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / drug effects
Epithelium / drug effects,  metabolism
Estradiol / pharmacology
Estrogens / pharmacology*
Female
Gene Expression Profiling*
Homeostasis / genetics*
Iron / metabolism*
Mice
Models, Biological
Uterus / drug effects*,  growth & development*
Chemical
Reg. No./Substance:
0/Estrogens; 50-28-2/Estradiol; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A spreadsheet model for developing field indicators and grazing management tools to meet environment...
Next Document:  Ruptured hemangioma of the umbilical cord and intrauterine fetal death, with review data.