Document Detail

Induction of intestinal adenocarcinomas by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Nagase analbuminemic rats.
MedLine Citation:
PMID:  1904414     Owner:  NLM     Status:  MEDLINE    
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), the most abundant mutagenic heterocyclic amine in cooked foods, was examined for carcinogenic potential using Nagase analbuminemic rats (NARs), which are sensitive to various carcinogens. The concentration of PhIP in the diet was 0.04% at the beginning of the experiment, this being subsequently gradually reduced to 0.01% to avoid severe body weight loss. Ten of 13 treated NARs developed a total of 36 intestinal tumors within the 311-day experimental period. Among these, 22 were adenocarcinomas and 2 were adenomas of the small intestine, 4 were adenocarcinomas of the cecum and 8 were adenocarcinomas of the large intestine. The results suggest that PhIP could represent a significant risk to human populations exposed to foods containing heterocyclic amines.
M Ochiai; K Ogawa; K Wakabayashi; T Sugimura; S Nagase; H Esumi; M Nagao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of cancer research : Gann     Volume:  82     ISSN:  0910-5050     ISO Abbreviation:  Jpn. J. Cancer Res.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-07-17     Completed Date:  1991-07-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8509412     Medline TA:  Jpn J Cancer Res     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  363-6     Citation Subset:  IM    
Carcinogenesis Division, National Cancer Center Research Institute, Tokyo.
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MeSH Terms
Adenocarcinoma / chemically induced*
Adenoma / chemically induced
Albumins / metabolism
Carcinogenicity Tests
Food Contamination
Imidazoles / toxicity*
Intestinal Neoplasms / chemically induced*
Pancreatic Neoplasms / chemically induced
Rats, Mutant Strains
Reg. No./Substance:
0/Albumins; 0/Imidazoles; 0/Mutagens; 105650-23-5/2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

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