Document Detail

Induction of insulin-like growth factor I messenger RNA in rat aorta after balloon denudation.
MedLine Citation:
PMID:  2188750     Owner:  NLM     Status:  MEDLINE    
Insulin-like growth factor I (IGF-I) is a widely distributed mitogen that mediates the growth-promoting effects of platelet-derived growth factor in mesenchymal cells. We show that rat aortic IGF-I messenger RNA (mRNA) is induced 24 hours after deendothelialization, at a time when smooth muscle cell proliferation within the intima is still not apparent. After 7 days, IGF-I mRNA induction peaks at about ninefold control levels and then falls to about threefold 14 days after denudation when smooth muscle cell proliferation is at its peak. We also show that, of the 5' untranslated IGF-I mRNA transcripts, only the class C transcript is expressed and regulated in aortic tissue. In contrast, treatment of rats with supraphysiological doses of growth hormone, the major endocrine regulator of IGF-I gene expression, elicited only twofold induction of aortic IGF-I mRNA. Our findings suggest that IGF-I may be an important autocrine or paracrine regulator of smooth muscle cell proliferation and that it may be significant in determining the cellular response to arterial wall injury.
B Cercek; M C Fishbein; J S Forrester; R H Helfant; J A Fagin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  66     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-07-05     Completed Date:  1990-07-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1755-60     Citation Subset:  IM    
Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA 90048-0750.
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MeSH Terms
Aorta / metabolism*
Balloon Dilatation
Endothelium, Vascular / physiology*
Growth Hormone / pharmacology
Histological Techniques
Insulin-Like Growth Factor I / genetics*
RNA, Messenger / metabolism*
Rats, Inbred Strains
Somatomedins / genetics*
Grant Support
Reg. No./Substance:
0/RNA, Messenger; 0/Somatomedins; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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