Document Detail


Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1.
MedLine Citation:
PMID:  10417778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Almost any growth of tumors is to some extent associated with an inflammatory reaction which may be anti-tumorigenic by acting directly on tumor cells or protumorigenic cells presumably by inducing tumor-associated angiogenesis. In this study, we have analyzed the angiogenesis-inducing capacity of monocyte chemoattractant protein-1 (MCP-1), a key regulatory molecule of monocyte trafficking to sites of inflammation. MCP-1 was found to be potently angiogenic when implanted into rabbit cornea, exerting potency similar to the specific angiogenic vascular endothelial growth factor (VEGF)-A(121). MCP-1-induced angiogenesis in the cornea is associated with prominent recruitment of macrophages, whereas VEGF-A(121)-induced corneal angiogenesis is devoid of inflammatory cell recruitment. Based on these findings, we studied MCP-1 expression and macrophage recruitment in human invasive ductal mammary carcinomas in comparison with the physiological angiogenic processes in bovine ovarian corpus luteum. Macrophage recruitment was always associated with MCP-1 expression. High macrophage counts in mammary tumors corresponded with poor prognosis. In contrast, physiological ovarian angiogenesis was associated with only minimal inflammatory recruitment of macrophages. Our data show that MCP-1 is an indirect inflammation-associated inducer of angiogenesis and demonstrate distinct qualitative differences between tumor angiogenesis in human mammary tumors and physiological angiogenesis in the ovary.
Authors:
V Goede; L Brogelli; M Ziche; H G Augustin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  82     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-08-13     Completed Date:  1999-08-13     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  765-70     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Wiley-Liss, Inc.
Affiliation:
Cell Biology Laboratory, Department of Gynecology and Obstetrics, University of Göttingen Medical School, Göttingen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Breast Neoplasms / blood supply,  pathology
Carcinoma, Ductal, Breast / blood supply,  pathology
Cattle
Chemokine CCL2 / physiology*
Cornea / blood supply
Corpus Luteum / blood supply,  pathology
Endothelial Growth Factors / physiology
Female
Humans
Lymphokines / physiology
Macrophages / physiology
Neovascularization, Pathologic / physiopathology*
Ovary / blood supply,  pathology
Rabbits
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Chemical
Reg. No./Substance:
0/Chemokine CCL2; 0/Endothelial Growth Factors; 0/Lymphokines; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors

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