| Induction of human cytotoxic T lymphocytes by oxidized low density lipoproteins. | |
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MedLine Citation:
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PMID: 8668916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxidized low density lipoproteins (oxLDL) stimulated human blood T cells to a specific cytotoxic response with autologous PHA activated blood mononuclear cells which had been pre-incubated with oxLDL. The cytotoxic reaction was exerted by CD8+ enriched cells but not by CD4+ enriched cells. Allogeneic target cells from HLA mismatched donors were not damaged and the reaction was consistently inhibited by monoclonal antibody against HLA class I. Antigen-specific cytotoxic T cells might contribute to lysis of cells in the atherosclerotic plaque that have taken up oxLDL and thus participate in the inflammatory process associated with atherosclerosis. |
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Authors:
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R Wu; R Giscombe; G Holm; A K Lefvert |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of immunology Volume: 43 ISSN: 0300-9475 ISO Abbreviation: Scand. J. Immunol. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-08-05 Completed Date: 1996-08-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0323767 Medline TA: Scand J Immunol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 381-4 Citation Subset: IM |
Affiliation:
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Immunological Research Laboratory, Department of Medicine, Karolinska Hospital, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cytotoxicity Tests, Immunologic Cytotoxicity, Immunologic / drug effects* Epitopes / drug effects HLA Antigens / classification, immunology Humans Lipoproteins, LDL / immunology*, metabolism, pharmacology* Lymphocyte Activation / drug effects* Oxidation-Reduction T-Lymphocytes, Cytotoxic / drug effects*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Epitopes; 0/HLA Antigens; 0/Lipoproteins, LDL; 0/oxidized low density lipoprotein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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