Document Detail


Induction of hippocampal neurogenesis by a tolerogenic peptide that ameliorates lupus manifestations.
MedLine Citation:
PMID:  21129786     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
To determine the effect of the tolerogenic peptide hCDR1 on hippocampal neurogenesis, we treated SLE-afflicted (NZBxNZW)F1 mice with hCDR1 (once a week for 10weeks). The treatment resulted in the up-regulation of neurogenesis in the dentate gyrus and restored the NeuN immunoreactivity in brain hippocampi of the mice in association with increased gene expression of IGF-1, NGF and BDNF. Furthermore, hCDR1 treatment significantly up-regulated p-ERK and p-Akt that are suggested to be key components in mediating growth factor-induced neurogenesis. The observed effects of hCDR1 on hippocampal-neurogenesis and on associated signaling pathways suggest a potential role for hCDR1 in CNS lupus.
Authors:
Alona Telerman; Smadar Lapter; Amir Sharabi; Heidy Zinger; Edna Mozes
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Publication Detail:
Type:  Journal Article     Date:  2010-12-03
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  232     ISSN:  1872-8421     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  151-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
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