Document Detail


Induction of hepatocellular carcinoma in nonhuman primates by chemical carcinogens.
MedLine Citation:
PMID:  2559797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several compounds were evaluated in nonhuman primates for their potential to induce neoplasms, especially hepatocellular carcinoma (HCC). The compounds can be classified into three groups: food contaminants, model rodent carcinogens, and nitrosamines. All three compounds in the food contaminants group, namely, aflatoxin B1, sterigmatocystin, and methylazoxymethanol acetate, induced HCC. None of the model rodent carcinogens tested consistently induced HCC in rhesus and cynomolgus monkeys. Three of four nitrosamines evaluated induced HCC in rhesus and cynomolgus monkeys. One nitrosamine, diethylnitrosamine, is a predictable and potent inducer of HCC and is useful for establishment of a nonhuman primate model for numerous oncologic studies.
Authors:
R H Adamson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer detection and prevention     Volume:  14     ISSN:  0361-090X     ISO Abbreviation:  Cancer Detect. Prev.     Publication Date:  1989  
Date Detail:
Created Date:  1990-03-22     Completed Date:  1990-03-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7704778     Medline TA:  Cancer Detect Prev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  215-9     Citation Subset:  IM    
Affiliation:
Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
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MeSH Terms
Descriptor/Qualifier:
2-Acetylaminofluorene
Aflatoxins
Animals
Carcinogens, Environmental / adverse effects
Carcinoma, Hepatocellular / chemically induced*
Cercopithecus aethiops
Environmental Pollutants / adverse effects
Female
Food Additives / adverse effects
Liver Neoplasms / chemically induced*
Macaca fascicularis
Macaca mulatta
Male
Methylazoxymethanol Acetate
Methyldimethylaminoazobenzene
Nitrosamines
Sterigmatocystin
Urethane
p-Dimethylaminoazobenzene
Grant Support
ID/Acronym/Agency:
N01-CP-51013/CP/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Aflatoxins; 0/Carcinogens, Environmental; 0/Environmental Pollutants; 0/Food Additives; 0/Nitrosamines; 10048-13-2/Sterigmatocystin; 51-79-6/Urethane; 53-96-3/2-Acetylaminofluorene; 55-80-1/Methyldimethylaminoazobenzene; 592-62-1/Methylazoxymethanol Acetate; 60-11-7/p-Dimethylaminoazobenzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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