Document Detail


Induction of hepatic CYP1A activity as a biomarker for environmental exposure to Aroclor 1254 in feral rodents.
MedLine Citation:
PMID:  1616319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Specimens of the feral mouse species Reithrodontomys fulvescens trapped from a polychlorinated biphenyl (PCB)-contaminated field location had hepatic ethoxyresorufin (ETR) O-dealkylase activities and immunoreactive CYP1A protein contents which were two- to threefold higher than those measured in animals of the same species and sex collected from non PCB-contaminated reference sites. Specimens with hepatic ETR O-dealkylase activities differing by as little as 50% could readily be assigned as originating from the PCB or reference sites by the use of a specific chemical inhibitor of cytochrome P450IA (CYP1A). The relative levels of ETR O-dealkylase activity in R. fulvescens significantly correlated with hepatic PCB burdens (r = 0.819, P less than 0.01). When the magnitudes of the induced ETR O-dealkylase activities corresponding to given hepatic PCB burdens were compared between the feral animals, F344/NCr rats (Rattus norvegicus) or B6C3F1 mice (Mus musculus) exposed in the laboratory to dietary Aroclor 1254, the order of sensitivity to the inducing effects of PCBs were F344/NCr rat greater than B6C3F1 mouse greater than R. fulvescens.
Authors:
R A Lubet; R W Nims; L E Beebe; S D Fox; H J Issaq; K McBee
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of environmental contamination and toxicology     Volume:  22     ISSN:  0090-4341     ISO Abbreviation:  Arch. Environ. Contam. Toxicol.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-07-27     Completed Date:  1992-07-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0357245     Medline TA:  Arch Environ Contam Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  339-44     Citation Subset:  IM    
Affiliation:
Laboratory of Comparative Carcinogenesis, National Cancer Institute, PRI-DynCorp, Frederick Cancer Research and Development Center, Maryland 21702-1201.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aroclors / toxicity*
Biological Markers
Body Burden
Carcinogens / toxicity*
Chlorodiphenyl (54% Chlorine)
Cytochrome P-450 CYP1A1
Cytochrome P-450 Enzyme System / biosynthesis*
Environmental Exposure
Female
Liver / drug effects*,  enzymology
Male
Mice
Oxidoreductases / biosynthesis*
Polychlorinated Biphenyls / metabolism
Rats
Rats, Inbred F344
Species Specificity
Grant Support
ID/Acronym/Agency:
N01-CO-74102/CO/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Aroclors; 0/Biological Markers; 0/Carcinogens; 0/Polychlorinated Biphenyls; 11097-69-1/Chlorodiphenyl (54% Chlorine); 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.-/Oxidoreductases; EC 1.14.14.1/Cytochrome P-450 CYP1A1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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