Document Detail


Induction of the 72 kDa heat shock protein by glucose ingestion in black pregnant women.
MedLine Citation:
PMID:  23325573     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obese Black women are at increased risk for development of gestational diabetes mellitus and have worse perinatal outcomes than do obese women of other ethnicities. Since hsp72 has been associated with the regulation of obesity-induced insulin resistance, we evaluated associations between glucose ingestion, hsp72 release and insulin production in Black pregnant women. Specifically, the effect of a 50-g glucose challenge test (GCT) on heat shock protein and insulin levels in the circulation 1 h later was evaluated. Hsp27 and hsp60 levels remained unchanged. In contrast, serum levels of hsp72 markedly increased after glucose ingestion (p = 0.0054). Further analysis revealed that this increase was limited to women who were not obese (body mass index <30). Insulin levels pre-GCT were positively correlated with body mass index (p = 0.0189). Median insulin concentrations also increased post GCT in non-obese women but remained almost unchanged in obese women. Post-GCT serum hsp72 concentrations were inversely correlated with post GCT insulin concentrations (p = 0.0111). These observations suggest that glucose intake during gestation in Black women rapidly leads to an elevation in circulating hsp72 only in non-obese Black women. The release of hsp72 may regulate the extent of insulin production in response to a glucose challenge and, thereby, protect the mother and/or fetus from development of hyperglycemia, hyperinsulinemia, and/or immune system alterations.
Authors:
Shirlee Jaffe; Georgios Doulaveris; Theofano Orfanelli; Mariana Arantes; Débora Damasceno; Iracema Calderon; Marilza V C Rudge; Steven S Witkin
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Publication Detail:
Type:  Journal Article     Date:  2013-01-17
Journal Detail:
Title:  Cell stress & chaperones     Volume:  18     ISSN:  1466-1268     ISO Abbreviation:  Cell Stress Chaperones     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-14     Completed Date:  2013-12-30     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  9610925     Medline TA:  Cell Stress Chaperones     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  527-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
African Americans
Body Mass Index
Chaperonin 60 / blood
Eating
Female
Glucose / metabolism*
Glucose Tolerance Test
HSP27 Heat-Shock Proteins / blood
HSP72 Heat-Shock Proteins / blood*
Humans
Insulin / metabolism
Mitochondrial Proteins / blood
Obesity / metabolism,  pathology
Pregnancy
Chemical
Reg. No./Substance:
0/Chaperonin 60; 0/HSP27 Heat-Shock Proteins; 0/HSP72 Heat-Shock Proteins; 0/HSPD1 protein, human; 0/Insulin; 0/Mitochondrial Proteins; IY9XDZ35W2/Glucose
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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