Document Detail

Induction of graft-versus-host disease after autologous bone marrow transplantation.
MedLine Citation:
PMID:  2564566     Owner:  NLM     Status:  MEDLINE    
To induce graft-versus-host disease (GvHD) in patients undergoing autologous bone marrow transplantation (BMT), five consecutive patients with non-Hodgkin lymphoma or Hodgkin's disease in resistant relapse were treated with cyclophosphamide and total body irradiation or busulphan and cyclophosphamide, followed by autologous BMT. The patients received cyclosporin 1 mg/kg per day intravenously for 28 days after BMT. Histologically proven grade II acute GvHD of the skin developed in all the patients at a median of 11 days (range 9-13) after BMT. One patient died and the GvHD resolved in 1-3 weeks in the four remaining patients--spontaneously in two and with corticosteroid treatment in two. Lymphocytes from one patient obtained at the time of GvHD were cytotoxic for the patient's own pretransplant lymphocytes. Cytotoxicity was blocked by antibodies directed against class II histocompatibility (HLA-DR or Ia) antigens. Cyclosporin-induced GvHD after autologous BMT resembles mild GvHD after allogeneic grafting. This syndrome appears to be mediated by autoreactive Ia-specific lymphocytes.
R J Jones; G B Vogelsang; A D Hess; E R Farmer; R B Mann; R B Geller; S Piantadosi; G W Santos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-05     Completed Date:  1989-05-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  754-7     Citation Subset:  AIM; IM    
Johns Hopkins Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.
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MeSH Terms
Acute Disease
Autoimmune Diseases / chemically induced*
Bone Marrow Transplantation*
Chronic Disease
Cyclosporins / adverse effects*
Graft vs Host Disease / chemically induced*,  immunology
Histocompatibility Antigens Class II / immunology
Hodgkin Disease / immunology,  therapy*
Lymphoma, Non-Hodgkin / immunology,  therapy*
Middle Aged
Skin Diseases / chemically induced*,  immunology
T-Lymphocytes, Cytotoxic / immunology
Transplantation, Autologous
Grant Support
Reg. No./Substance:
0/Cyclosporins; 0/Histocompatibility Antigens Class II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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