| Induction of graft-versus-host disease after autologous bone marrow transplantation. | |
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MedLine Citation:
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PMID: 2564566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To induce graft-versus-host disease (GvHD) in patients undergoing autologous bone marrow transplantation (BMT), five consecutive patients with non-Hodgkin lymphoma or Hodgkin's disease in resistant relapse were treated with cyclophosphamide and total body irradiation or busulphan and cyclophosphamide, followed by autologous BMT. The patients received cyclosporin 1 mg/kg per day intravenously for 28 days after BMT. Histologically proven grade II acute GvHD of the skin developed in all the patients at a median of 11 days (range 9-13) after BMT. One patient died and the GvHD resolved in 1-3 weeks in the four remaining patients--spontaneously in two and with corticosteroid treatment in two. Lymphocytes from one patient obtained at the time of GvHD were cytotoxic for the patient's own pretransplant lymphocytes. Cytotoxicity was blocked by antibodies directed against class II histocompatibility (HLA-DR or Ia) antigens. Cyclosporin-induced GvHD after autologous BMT resembles mild GvHD after allogeneic grafting. This syndrome appears to be mediated by autoreactive Ia-specific lymphocytes. |
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Authors:
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R J Jones; G B Vogelsang; A D Hess; E R Farmer; R B Mann; R B Geller; S Piantadosi; G W Santos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Lancet Volume: 1 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1989 Apr |
Date Detail:
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Created Date: 1989-05-05 Completed Date: 1989-05-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 754-7 Citation Subset: AIM; IM |
Affiliation:
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Johns Hopkins Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Autoimmune Diseases / chemically induced* Bone Marrow Transplantation* Chronic Disease Cyclosporins / adverse effects* Female Graft vs Host Disease / chemically induced*, immunology Histocompatibility Antigens Class II / immunology Hodgkin Disease / immunology, therapy* Humans Lymphoma, Non-Hodgkin / immunology, therapy* Male Middle Aged Skin Diseases / chemically induced*, immunology T-Lymphocytes, Cytotoxic / immunology Transplantation, Autologous |
| Grant Support | |
ID/Acronym/Agency:
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AI24319/AI/NIAID NIH HHS; CA15396/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cyclosporins; 0/Histocompatibility Antigens Class II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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