Document Detail

Induction of functional MT1 and MT2 isoforms by calcium in anaplastic thyroid carcinoma cells.
MedLine Citation:
PMID:  17485079     Owner:  NLM     Status:  MEDLINE    
Metallothionein (MT) expression in carcinogenesis of thyrocytes is unknown. We demonstrated that cadmium induced transcription of all functional MT-1 and MT-2 isoforms and promoted the cell cycle from the G1 to the S phase in thyroid cancer cells, which can be suppressed by the ERK inhibitor. Cadmium exposure stimulated intracellular calcium and the phosphorylation of ERK1/2. Therefore, a common pathway initiated by a rapid rise in calcium and followed by calcium-mediated activation of ERK is involved in the transcriptional induction of functional MT1 and MT2 isoforms and in the progression of the cell cycle in thyroid cancer cells exposed to cadmium.
Zhi-Min Liu; George G Chen; Cathy K Y Shum; Alexander C Vlantis; M George Cherian; James Koropatnick; C Andrew van Hasselt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-04-30
Journal Detail:
Title:  FEBS letters     Volume:  581     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-25     Completed Date:  2007-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2465-72     Citation Subset:  IM    
Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.
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MeSH Terms
Calcium / pharmacology,  physiology*
Cell Cycle
Cell Line, Tumor
DNA Primers
Metallothionein / biosynthesis*,  genetics
Polymerase Chain Reaction
Protein Isoforms / biosynthesis
RNA, Neoplasm / genetics
Thyroid Neoplasms
Reg. No./Substance:
0/DNA Primers; 0/Protein Isoforms; 0/RNA, Neoplasm; 7440-70-2/Calcium; 9038-94-2/Metallothionein

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