Document Detail


Induction of formaldehyde contact sensitivity: dose response relationship in the guinea pig maximization test.
MedLine Citation:
PMID:  2420109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sensitizing potential of aqueous formaldehyde was evaluated with the guinea pig maximization test (GPMT) in two laboratories (Copenhagen and Stockholm) using different guinea pig strains. Six intradermal (0.01%-3%), and 6 topical (0.5%-20%) concentrations were used for induction, and formaldehyde 1% and 0.1% was used for challenge. The incidence of contact sensitivity depended on the intradermal, but not on the topical induction dose. Statistical analyses showed a non-monotonous (non-linear) dose response relationship. The estimated maximal sensitization rate in Copenhagen was 80% after intradermal induction with 0.65% formaldehyde; in Stockholm it was 84% after induction with 0.34%. The data from the two laboratories could be described by parallel displaced dose response curves suggesting that the guinea pig strain used in Stockholm was significantly more susceptible to formaldehyde than the strain used in Copenhagen. The EC50 (formaldehyde concentration at which 50% of the guinea pigs were sensitized) at the 72 h scoring and a 1% challenge concentration, was 0.061% in Copenhagen and 0.024% in Stockholm.
Authors:
K E Andersen; A Boman; A Vølund; J E Wahlberg
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  65     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1985  
Date Detail:
Created Date:  1986-03-31     Completed Date:  1986-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  472-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Animals
Dermatitis, Contact / immunology*
Dose-Response Relationship, Immunologic
Female
Formaldehyde / administration & dosage,  immunology*
Guinea Pigs
Intradermal Tests
Skin Tests
Solutions
Chemical
Reg. No./Substance:
0/Solutions; 50-00-0/Formaldehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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