Document Detail

Induction of fatty acid-binding protein 3 in brown adipose tissue correlates with increased demand for adaptive thermogenesis in rodents.
MedLine Citation:
PMID:  18938135     Owner:  NLM     Status:  MEDLINE    
We investigated the contribution of fatty acid-binding protein 3 (FABP3) to adaptive thermogenesis in brown adipose tissue (BAT) in rodents. The expression of FABP3 mRNA in BAT was regulated discriminatively in response to alteration of the ambient temperature, which regulation was similar and reciprocal to the regulation of uncoupling protein 1 (UCP1) and leptin, respectively. FABP3 expression in the BAT was significantly higher in the UCP1-knockout (KO) mice than in the wild-type ones, and these KO mice showed a higher clearance rate of free fatty acid from the plasma. In addition, FABP3 expression in the BAT was increased greatly with the development of diet-induced obesity in mice. These results indicate that the induction of FABP3 in BAT correlates with an increased demand for adaptive thermogenesis in rodents. FABP3 appears to be essential for accelerating fatty acid flux and its oxidation through UCP1 activity for non-shivering thermogenesis in BAT.
Hitoshi Yamashita; Zuocheng Wang; Youxue Wang; Masahiko Segawa; Tatsuya Kusudo; Yasuhide Kontani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-18
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  377     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-14     Completed Date:  2008-12-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  632-5     Citation Subset:  IM    
Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai 487-8501, Japan.
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MeSH Terms
Adaptation, Physiological* / genetics
Adipose Tissue, Brown / metabolism*
Fatty Acid-Binding Proteins / genetics,  physiology*
Ion Channels / metabolism
Mice, Knockout
Mitochondrial Proteins / metabolism
Rats, Wistar
Thermogenesis* / genetics
Reg. No./Substance:
0/Fabp3 protein, mouse; 0/Fatty Acid-Binding Proteins; 0/Ion Channels; 0/Mitochondrial Proteins; 0/mitochondrial uncoupling protein

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