| Induction and expression rules of synaptic plasticity in hippocampal interneurons. | |
| | |
MedLine Citation:
|
PMID: 21195098 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The knowledge that excitatory synapses on aspiny hippocampal interneurons can develop genuine forms of activity-dependent remodeling, independently from the surrounding network of principal cells, is a relatively new concept. Cumulative evidence has now unequivocally demonstrated that, despite the absence of specialized postsynaptic spines that serve as compartmentalized structure for intracellular signaling in principal cell plasticity, excitatory inputs onto interneurons can undergo forms of synaptic plasticity that are induced and expressed autonomously from principal cells. Yet, the rules for induction and expression of interneuron plasticity are much more heterogeneous than in principal neurons. Long-term plasticity in interneurons is not necessarily dependent upon postsynaptic activation of NMDA receptors nor relies on the same postsynaptic membrane potential requirements as principal cells. Plasticity in interneurons rather requires activation of Ca(2+)-permeable AMPA receptors and/or metabotropic glutamate receptors and is triggered by postsynaptic hyperpolarization. In this review we will outline these distinct features of interneuron plasticity and identify potential critical candidate molecules that might be important for sustaining long-lasting changes in synaptic strength at excitatory inputs onto interneurons. |
| | |
Authors:
|
Fernanda Laezza; Raymond Dingledine |
Related Documents
:
|
16051748 - Roscovitine triggers excitotoxicity in cultured granule neurons by enhancing glutamate ... 1386178 - Nmda receptor-mediated arachidonic acid release in neurons: role in signal transduction... 21522138 - Ligand-specific deactivation time course of glun1/glun2d nmda receptors. 12533598 - Epsilon pkc is required for the induction of tolerance by ischemic and nmda-mediated pr... 11771768 - A potential role for the p75 low-affinity neurotrophin receptor in spinal motor neuron ... 17715188 - Patch-clamp analysis of gene-targeted vomeronasal neurons expressing a defined v1r or v... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2010-12-30 |
Journal Detail:
|
Title: Neuropharmacology Volume: - ISSN: 1873-7064 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2011-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0236217 Medline TA: Neuropharmacology Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
University Texas Medical Branch, Department of Pharmacology & Toxicology, 301 University Boulevard, Galveston, TX 77555, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Role of microcircuit structure and input integration in hippocampal interneuron recruitment and plas...
Next Document: Direct inhibition of hypocretin/orexin neurons in the lateral hypothalamus by nociceptin/orphanin FQ...