Document Detail


Induction of exocrine pancreas maturation at weaning in young developing pigs.
MedLine Citation:
PMID:  8492258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of weaning, at either 4 or 6 weeks of age, on the maturation of the exocrine pancreas was studied in naturally reared Swedish Landrace pigs that had no access to solid food. The pigs were surgically fitted with chronic catheters at 3 weeks of age, permitting periodic sampling of pancreatic juice and blood in conscious animals < or = 4 weeks after weaning. During the suckling period, pancreatic fluid and enzyme secretion remained low, both before (preprandial) and after (postprandial) milk ingestion. After weaning at 4 or 6 weeks of age, juice secretion, output of total protein, and levels of different hydrolases (amylase, trypsin, lipase, and carboxylester lipase) and the cofactor colipase all increased markedly postprandially. Moreover, after weaning, the plasma insulin level increased postprandially. This did not happen before weaning, although blood glucose levels always rose after feeding. The data showed a relationship between the time of weaning and the induction of exocrine pancreatic maturation in pigs. This finding implies that postnatal development of pancreatic function is triggered by the dietary change from sow milk to dry solid food. In contrast, the age of the pig appears to be of minor importance, since weaning at either 4 or 6 weeks of age gave a similar result.
Authors:
S G Pierzynowski; B R Weström; C Erlanson-Albertsson; B Ahre'n; J Svendsen; B W Karlsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  16     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-06-15     Completed Date:  1993-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  287-93     Citation Subset:  IM    
Affiliation:
Department of Animal Physiology, University of Lund, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Blood Glucose / analysis
Hydrolases / analysis
Insulin / blood
Pancreas / enzymology,  growth & development,  secretion*
Pancreatic Juice / enzymology,  secretion
Swine
Weaning*
Chemical
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; EC 3.-/Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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